Pharma Excipients
Calcium CarbonateCMC and Croscarmellose Sodium
Channelled tablets: An innovative approach to accelerating drug release from 3D printed tablets
Conventional immediate release dosage forms involve compressing the powder with a disintegrating agent that enables rapid disintegration and dissolution upon oral ingestion. Among 3D printing technologies, the fused deposition modelling (FDM) 3D printing technique has a considerable potential for…
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Improved Dissolution and Pharmacokinetics of Abiraterone through KinetiSol® Enabled Amorphous Solid…
Abiraterone is a poorly water-soluble drug. It has a high melting point and limited solubility in organic solvents, making it difficult to formulate as an amorphous solid dispersion (ASD) with conventional technologies. KinetiSol® is a high-energy, fusion-based, solvent-free technology that can…
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A systematic evaluation of poloxamers as tablet lubricants
Lubricants are important for both preserving the tooling of high-speed tablet presses and attaining quality tablets. Magnesium stearate (MgSt) is most commonly used due to its superior lubrication efficiency; however, it can lead to negative effects on tabletability and dissolution.
In this…
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Predictive Model-Based Process Start-Up in Pharmaceutical Continuous Granulation and Drying
Continuous manufacturing (CM) is a promising strategy to achieve various benefits in the context of quality, flexibility, safety and cost in pharmaceutical production.
One of the main technical challenges of CM is that the process needs to handle transient conditions such as the start-up phase…
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Amorphous Solid Dispersion Formation via Solvent Granulation – A Case Study with Ritonavir and…
With an increase in the number of therapeutically active compounds exhibiting low water solubility, formulation strategies such as amorphization, salt formation, complexation, micellization, are increasingly employed to improve solubility and bioavailability. Among these, amorphous formulations,…
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Mucoadhesive hydrogels for buccal drug delivery
It was the aim of the study to assess in vitro methods for the characterization of mucoadhesive hydrogels for their potential to predict the residence time on human buccal mucosa.
Methods
Mixtures of hydrogels comprising hydroxyethyl cellulose (HEC), sodium carboxymethyl cellulose (CMC),…
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Predicting the critical quality attributes of ibuprofen tablets via modelling of process parameters…
Roller compaction is a low cost granulation process which application is sometimes limited by the granular loss of compactability and reduced drug dissolution rate. Hence, the design of a robust manufacturing process is key in order to ensure quality of tablets.
In this study, for ibuprofen…
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Design and evaluation of novel inhalable sildenafil citrate spray-dried microparticles for pulmonary…
Pulmonary delivery of vasodilators is a promising alternative for the intravenous and oral treatment of pulmonary arterial hypertension (PAH). The aim of this study was to design and evaluate hydrogel microparticles as a carrier for sustained pulmonary delivery of sildenafil citrate. Spray dried…
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The Use of 3D Printed Molds to Cast Tablets with a Designed Disintegration Profile
Development of new product design principles is crucial for obtaining pharmaceutical products with controlled functionality. Four different molds were designed using a computer-aided design (CAD) software and 3D printed with polylactic acid (PLA). A hydroxypropyl methylcellulose (HPMC) and…
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Sigachi receives “National Best Employer BRANDS 2018” Award
Taj Lands End, Mumbai, 16 Feb 2019. One of the leading excipient manufacturer, Sigachi, announced the receipt of the highly coveted National Best Employer Brands 2018 in the 13th Employer Branding Awards, organized as part of 27th edition of World HRD Congress(http://www.worldhrdcongress.com)
The…
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