Pharma Excipients
Calcium CarbonateCMC and Croscarmellose Sodium
In Vivo Evaluation of a Gastro-Resistant Enprotect® Capsule under Postprandial Conditions
Ready-to-fill enteric hard capsule shells are an evolving field of oral drug and nutraceutical products. Lonza Capsugel® Enprotect® capsules were recently proven to provide reliable release in the small intestine after fasted intake, but robustness against postprandial intake needed to be proven. In…
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Application of Response Surface Methodology to Improve the Tableting Properties of Poorly…
Designing a robust direct compression (DC) formulation for an active pharmaceutical ingredient (API) with poor flow and compaction properties at a high API load is challenging. This study tackled two challenges: the unfavorable flow characteristics and tableting problems associated with a…
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IFF and BASF collaborate on the Virtual Pharma Assistant Platform ZoomLab™
PRESS RELEASE
NEW YORK — Nov. 8, 2023 — IFF and BASF today announced a collaboration between the Pharma Solutions divisions of both companies, to onboard IFF’s leading product brands in pharmaceutical excipients into BASF’s Virtual Pharma Assistant platform – ZoomLab™. The platform is a…
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Design of experiments approach on the compaction properties of co-amorphous tablets
Co-amorphous systems are an evolving strategy to stabilize the amorphous form of a drug molecule with the aim of overcoming its poor water-solubility. With research focussing on the molecular level of co-amorphous systems, little is known about their downstream processing. In this study, tablets of…
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Comparative Evaluation of Particle Size Reduction, Salt Formation, and Amorphous Formulation on the…
Various approaches have been developed to enhance the solubility or dissolution rate for the delivery of poorly water-soluble molecules. In this work, guided by an in silico solubility sensitivity analysis for oral absorption, a comparative assessment of the biopharmaceutical performance of a…
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Fenofibrate loaded nanofibers based thermo-responsive gel for ocular delivery: Formulation…
This research work is to develop nanofiber loaded in -situ gel for the delivery of fenofibrate to the posterior ocular site. Fenofibrate had showed its efficacy in neovascular ocular diseases under clinical studies but its low aqueous solubility makes difficult to develop a suitable ocular…
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Quality attributes for printable emulsion gels and 3D-printed tablets: Towards production of…
3D-printing technology offers a flexible manufacturing platform with the potential to address the need of personalized dosage forms. However, quality aspects of such small-scale, on-demand production of pharmaceutical products intended for personalization is still limited. The aim of this study was…
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3D printing of carvedilol oral dosage forms using selective laser sintering technique
Introduction
The adjustment of the dose according to the individual needs of the patient is a unique advantage of 3D printing technology, which is of particular importance for the pediatric and geriatric population, due to the diverse needs and characteristics of these groups of patients (Kotta et…
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Study of Powder and Tableting Functionality Towards Evaluation and Characterisation of BARETab® PH…
Abstract
BARETab® PH is a multi-functional ready to use premixed, co-processed ingredient for direct compression (DC) formulations. It is a combination of selective, largely used excipients for DC. Direct compression is the most widely used tableting method because of the simple manufacturing…
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Comparison of properties on Orally Disintegrating Tablets (ODTs) produced by direct compression or…
Abstract
Orally disintegrating tablets (ODTs) is a popular drug delivery system as they dissolve in the mouth, usually within seconds which enables easy medication for patients with problem swallowing. In this thesis properties of ODTs were compared when produced with direct compression of the…
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