Pharma Excipients
Calcium CarbonateCMC and Croscarmellose Sodium
Effects of wet granulation process variables on the quantitative assay model of transmission Raman…
Transmission Raman spectroscopy (TRS) is a process analytical technology tool for nondestructive analysis of drug content in tablets. Although wet granulation is the most used tablet manufacturing method, most TRS studies have focused on tablets manufactured via direct compression. The effects of…
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Application of the Gradient boosted tree approach for thin film classification based on…
Introduction
Thin films are polymeric strips that disintegrate in the oral cavity and consist of a film-forming agent and an active pharmaceutical ingredient (API). Generally, thin films disintegrate within seconds, but their composition can be modified to allow slower disintegration and release of…
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The effect of excipients on oral lyophilizates quality attributes
Pharmaceutical industry is constantly focused on researching patient-centered dosage forms that can maximize the therapeutic potential of an active pharmaceutical ingredient, as for example orodispersible form. The main advantage of orodispersible dosage forms is that they are suitable for patients…
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Effect of geometrical features on the capping behavior of biconvex tablets
Abstract
Capping is a common industrial issue during the manufacturing of pharmaceutical tablets. It is influenced by both process and formulation parameters. In this work, a systematic study of the influence of the geometrical features of biconvex tablets on capping occurrence was performed on a…
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Drying capacity of a continuous vibrated fluid bed dryer – Statistical and mechanistic model…
The drying capacity of a continuous vibrated fluid bed dryer was studied using a DoE by varying microcrystalline cellulose content in the formulation, water amount in the twin-screw granulation, inlet air temperature, air flow rate and the acceleration of the horizontal fluid-bed. Temperature and…
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HiCel™ Silicified Microcrystalline Cellulose, Versatile Excipient for Nutraceutical Herbal Tablet…
Abstract
Nutraceutical herbal medicine and supplements demand increases day by day. Herbal medicine normally contains lipids, protein, carbohydrate, vitamins, minerals and other necessary nutrients depending upon their emphases. Generally, all herbal extracts powder nature is fine poor flowable,…
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Design, formulation, and evaluation of risperidone mucoadhensive buccal patches
Objectives: To construct and optimize Risperidone (RIS) mucoadhesive buccal films for systemic distribution as an alternate route. To make buccal patches of Risperidone utilizing natural polymers such sodium alginate (SA), Hydroxypropyl methylcellulose (HPMC), Na CMC, and Carbopol 934 (CP 934).…
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Redispersible 3D printed nanomedicines: An original application of the semisolid extrusion technique
Abstract
Semisolid extrusion is a layer-by-layer 3D printing technique that produces objects from gels or pastes. This process can be carried out at room temperature, without using a light source, and has been explored in pharmaceutics in the last few years. In this regard, our group hypothesized…
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The relationship between molecular-structural properties and functional-related characteristics of…
Croscarmellose sodium (CCS)is a superdisintegrant used in the formulation of pharmaceutical tablets. As with most other pharmaceutical ingredients, CCS is produced by various manufacturers. Our previous work has shown that products of different manufacturers can have varying properties and…
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A tabletability change classification system in supporting the tablet formulation design via the…
In this paper, the material library approach was used to uncover the pattern of tabletability change and related risk for tablet formulation design under the roll compaction and dry granulation (RCDG) process. 31 materials were fully characterized using 18 physical parameters and 9 compression…
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