Pharma Excipients
Calcium CarbonateCMC and Croscarmellose Sodium
At-line porosity sensing for non-destructive disintegration testing in immediate release tablets
Fully automated at-line terahertz time-domain spectroscopy in transmission mode is used to measure tablet porosity for thousands of immediate release tablets. The measurements are rapid and non-destructive. Both laboratory prepared tablets and commercial samples are studied. Multiple measurements on…
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Three-dimensional (3D) printing of oral dental films (ODFs) using blended Compactcel® polymers…
Abstract
This study aimed to prototype oral dental films (ODFs) loaded with diclofenac sodium (DS) using two different grades of CompactCel® polymers through a semi-solid extrusion (SSE) bioprinter. This three-dimensional (3D) printed ODFs were developed for the treatment of toothaches with…
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Pharmaceutical evaluation of Levofloxacin orally disintegrating tablet formulation using low…
We evaluated the pharmaceutical properties of levofloxacin (LV) in the form of an orally disintegrating tablet (LVODT) to find a new usefulness of low frequency (LF) Raman spectroscopy. LVODT contained dispersed granules with diameters in the order of several hundred micrometers, which were composed…
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Characterization and Validation of a New 3D Printing Ink for Reducing Therapeutic Gap in Pediatrics…
Abstract
3D printing technology can be used to develop individualized medicines in hospitals and pharmacies, allowing a high degree of personalization and the possibility to adjust the dose of the API based on the quantity of material extruded. The main goal of incorporating this technology is to…
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Eudragit® FS Microparticles Containing Bacteriophages, Prepared by Spray-Drying for Oral…
Phage therapy is recognized to be a promising alternative to fight antibiotic-resistant infections. In the quest for oral dosage forms containing bacteriophages, the utilization of colonic-release Eudragit® derivatives has shown potential in shielding bacteriophages from the challenges encountered…
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Preliminary Study on the Development of Caffeine Oral Solid Form 3D Printed by Semi-Solid Extrusion…
Apnea of prematurity can be treated with a body-weight-adjusted dosage of caffeine. Semi-solid extrusion (SSE) 3D printing represents an interesting approach to finely tailor personalized doses of active ingredients. To improve compliance and ensure the right dose in infants, drug delivery systems…
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The application of Near-Infrared Spatially Resolved Spectroscopy in scope of achieving continuous…
In scope of achieving real-time release of tablets, quality attributes need to be monitored and controlled through Process Analytical Technology tools such as near-infrared spectroscopy (NIRS). The authors evaluated the suitability of NIR-Spatially Resolved Spectroscopy (NIR-SRS) for continuous…
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Comparison of scale-up strategies in twin-screw wet granulation
The aim of this study was to compare different scale-up strategies in twin-screw wet granulation and investigate the impact of the selected strategy on granule and tablet properties for a defined formulation. For the scale-up, a granulation process was transferred from a QbCon® 1 with a screw…
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Comparison of Ceolus™ Grades in Continuous Manufacturing of Tablets using Direct Compression
1. Introduction
The introduction of continuous manufacturing of tablets has been gaining momentum, because it offers reductions in development and manufacturing costs and time and improved reliability of quality assurance.
In this study, grades of Ceolus™, microcrystalline cellulose (MCC) in…
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Long-acting Parenteral Drug Delivery Systems for the Treatment of Chronic Diseases
Abstract
The management of chronic conditions often requires patients to take daily medication for an extended duration. However, the need for daily dosing can lead to nonadherence to the therapy, which can result in the recurrence of the disease. Long-acting parenteral drug delivery systems have…
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