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HPC – hydroxypropyl cellulose
Converting a batch based high-shear granulation process to a continuous dry granulation process
When one wishes to convert a batch based manufacturing process of an existing tablet product to a continuous process, there are several available strategies which can be adopted. Theoretically, the most straightforward way would be to proceed with the corresponding processing principles, for example…
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Tailored granule properties using 3D printed screw geometries in twin screw granulation
Twin screw granulation is becoming increasingly relevant due to its compact size, continuous and robust mode of operation, customizable design, and flexible production capacity. This work describes the experimental study undertaken to understand the dependence of granule properties on the screw…
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3D printed opioid medicines with alcohol-resistant and abuse-deterrent properties
In the past decade, prescriptions for opioid medicines have been exponentially increasing, instigating opioid abuse as a global health crisis associated with high morbidity and mortality. In particular, diversion from the intended mode of opioid administration, such as injecting and snorting the…
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Direct powder extrusion 3D printing: Fabrication of drug products using a novel single-step process
Three-dimensional (3D) printing is revolutionising how we envision manufacturing in the pharmaceutical field. Here, we report for the first time the use of direct powder extrusion 3D printing: a novel single-step printing process for the production of printlets (3D printed tablets) directly from…
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Powder bed 3D-printing of highly loaded drug delivery devices with hydroxypropyl cellulose as solid…
3D-printing is a promising tool to pave the way to the widespread adaption of individualized medicine. Several printing techniques have been investigated and introduced to pharmaceutical research. Until now, only one 3D-printed medicine is approved on the US market. The medicine is manufactured via…
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Dual release and molecular mechanism of bilayered aceclofenac tablet using polymer mixture
Abstract
The objectives of the present study were to develop a controlled-release bilayered tablet of aceclofenac (AFN) 200 mg with dual release and to gain a mechanistic understanding of the enhanced sustained release capability achieved by utilizing a binary mixture of the sustained…
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Investigating the Use of Polymeric Binders in Twin Screw Melt Granulation Process for Improving…
Traditionally, the melt granulation for pharmaceutical products was performed at low temperature (<90°C) with high-shear granulators using low-melting waxy binders, and tablets produced using such granules were not amenable to large-scale manufacturing. The situation has changed in recent…
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Macroindentation hardness measurement – Modernization and applications
In this study, we first developed a modernized indentation technique for measuring tablet hardness. This technique is featured by rapid digital image capture, using a calibrated light microscope, and precise area-determination. We then systematically studied effects of key experimental…
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Design and Evaluation of Buccal Patch Containing Combination of Hydrochlorothiazide and Lisinopril
19. February 2016
Design and Evaluation of Buccal Patch Containing Combination of Hydrochlorothiazide and Lisinopril
Purpose: The objective of the present study was to formulate and evaluate buccal patches containing combination of lisinopril (LP) and hydrochlorothiazide (HCZ).…
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Ashland announces global price increase for vinyl pyrrolidone- and cellulosic-based pharmaceutical…
Ashland announces global price increase for vinyl pyrrolidone- and cellulosic-based pharmaceutical excipient products
WILMINGTON, Del. - Ashland Specialty Ingredients, a commercial unit of Ashland Inc. (NYSE: ASH), is increasing the price of its portfolio of Aqualon™ ethylcellulose and sodium…
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