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HPC – hydroxypropyl cellulose
Digital Compounding in Pharmacies: A Pilot Stability Study †
The manufacture of medicines on demand for a particular patient, at the point of care, may be achieved via 3D printing, improving therapeutic outcomes, medication adherence and patient safety. Tablets are often printed using a combination of hot-melt extrusion and fused deposition modelling. In this…
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The balance of physical stability and drug release in ternary fenofibrate/HPC/Eudragit L100-55…
Introduction
Amorphous solid dispersions are state-of the art enabling technique for poorly water soluble active pharmaceutical ingredients (APIs). In an ASD, the API is molecularly dissolved in a suitable polymer matrix that stabilizes the amorphous state during storage against recrystallization…
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Pellets and gummies: Seeking a 3D printed gastro-resistant omeprazole dosage for paediatric…
The production of 3D printed pharmaceuticals has thrived in recent years, as it allows the generation of customised medications in small batches. This is particularly helpful for patients who need specific doses or formulations, such as children. Compounding pharmacies seek alternatives to…
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Advances in the Development of Amorphous Solid Dispersions: the Role of Polymeric Carriers
Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs are dispersed at the molecular level. To prepare the solid dispersions, there are many polymers with various…
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Development of Lipid Polymer Hybrid Drug Delivery Systems Prepared by Hot-Melt Extrusion
This study sought to develop polymer-lipid hybrid solid dispersions containing the poorly soluble drug lopinavir (LPV) by hot-melt extrusion (HME). Hence, the lipid and polymeric adjuvants were selected based on miscibility and compatibility studies. Film casting was used to assess the miscibility,…
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Comparison between polymeric excipients using SeDeM expert system in combination with mathematical…
Based on the quality by design approach, we used the SeDeM expert system to assess seven polymers of different chemical nature and molecular weight for their use in direct compression. Because the SeDeM system fails by not evaluating the mechanical properties of materials, we used the Heckel and…
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3D Printing Technology: A New Approach for the Fabrication of Personalized and Customized…
3DP is a computer-aided design with the interesting innovation of prototyping layer-by-layer, creating 3D articles as digital blueprints to accomplish unequaled gracefulness, time protection, and extraordinary assembling ability of pharmaceutical dosage forms. 3D printing technology offers a novel…
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Personalizing oral delivery of nanoformed piroxicam by semi-solid extrusion 3D printing
Semi-solid extrusion (SSE) 3D printing enables flexible designs and dose sizes to be printed on demand and is a suitable tool for fabricating personalized dosage forms. Controlled Expansion of Supercritical Solution (CESS®) is a particle size reduction technology, and it produces particles of a pure…
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Planetary roller melt granulation (PRMG) – A new continuous method for powder processing
Abstract
For the continuous operation of granulation, which is a standard unit operation in powder processing to modify the particle size, the use of twin-screw machines was established as standard method for wet and melt granulation over the last decade. A main characteristic for this technology…
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Deep Learning-Based Machine Vision System for Use in High-Shear Granulation
Aim
Develop a prototype machine vision system and evaluate feasibility of a deep learning-based image analysis approach for estimation of the state of granulation on the acquired granule bulk surface images.
Introduction
Despite many decades of research in granulation technology, the…
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