Browsing Category
HPC – hydroxypropyl cellulose
3D screen printing technology enables fabrication of oral drug dosage forms with freely tailorable…
3D printing offers new opportunities to customize oral dosage forms of pharmaceuticals for different patient populations, improving patient safety, care, and compliance. Although several notable 3D print technologies have been developed, such as inkjet printing, powder-based printing, selective…
Read More...
Read More...
Pharmaceutical evaluation of Levofloxacin orally disintegrating tablet formulation using low…
We evaluated the pharmaceutical properties of levofloxacin (LV) in the form of an orally disintegrating tablet (LVODT) to find a new usefulness of low frequency (LF) Raman spectroscopy. LVODT contained dispersed granules with diameters in the order of several hundred micrometers, which were composed…
Read More...
Read More...
Eudragit® FS Microparticles Containing Bacteriophages, Prepared by Spray-Drying for Oral…
Phage therapy is recognized to be a promising alternative to fight antibiotic-resistant infections. In the quest for oral dosage forms containing bacteriophages, the utilization of colonic-release Eudragit® derivatives has shown potential in shielding bacteriophages from the challenges encountered…
Read More...
Read More...
Application of unsupervised and supervised learning to a material attribute database of tablets…
The purpose of this study is to demonstrate the usefulness of machine learning (ML) for analyzing a material attribute database from tablets produced at different granulation scales. High shear wet granulators (scale 30 g and 1000 g) were used and data were collected according to the design of…
Read More...
Read More...
SmartEx® Plus: a New Co-Processed Excipient for Oral Disintegration Tablets
SmartEx® Plus is an exciting new co-processed excipient that has been developed by Japanese chemical company Shin-Etsu to meet the increased demand for oral disintegration tablets (ODTs), with the added advantage that it offers excellent stability without compromising on disintegration time.
This…
Read More...
Read More...
Preparation of a ternary amorphous solid dispersion using hot-melt extrusion for obtaining a stable…
In our previous reports, ternary amorphous solid dispersions (ASDs) of probucol (PBC)/polymer/surfactant were prepared by spray-drying and cryo-grinding, and colloidal dispersions of amorphous PBC nanoparticles were obtained by dispersing the ternary ASD into water. In this study, hot-melt…
Read More...
Read More...
Formulation and in vitro Evaluation of Taste-Masked Orodispersible Tablets of Levocetirizine…
Abstract
The main aim was to formulate and evaluate and optimize taste- masked orodispersible tablets of Levocetirizine Dihydrochloride, a drug used in Allergic Rhinitis was prepared by direct compression method. The study involved different excipients which were used for the formulation and tested…
Read More...
Read More...
Evaluation of binders in twin-screw wet granulation – Optimal combination of binder and disintegrant
The influence of localization (intragranular, split or extragranular) of three superdisintegrants (croscarmellose sodium, crospovidone, sodium starch glycolate) on granules and tablets after twin-screw granulation was studied. The aim was to find a suitable disintegrant type and disintegrant…
Read More...
Read More...
Physiological buffer effects in drug supersaturation – a mechanistic study of hydroxypropyl…
Phosphate buffer is predominantly used instead of the more physiological bicarbonate buffer, as the latter requires a technical solution of adequate gas mixing. Recent pioneering work on how bicarbonate buffer affected drug supersaturation revealed interesting effects that call for more mechanistic…
Read More...
Read More...
Mucoadhesive drug delivery systems: a promising noninvasive approach to bioavailability enhancement.…
Abstract
Introduction
Mucoadhesive drug delivery systems (MDDS) are specifically designed to interact and bind to the mucosal layer of the epithelium for localized, prolonged, and/or targeted drug delivery. Over the past 4 decades, several dosage forms have been developed for localized as…
Read More...
Read More...