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HPC – hydroxypropyl cellulose
Neusilin® the extraordinary excipient for solid dosage forms – Technical Newsletter
See the third issue of Fuji Chemical Industries Technical Newsletter. This issue focuses on achieving higher tablet hardness with pleasant mouth feel at good oral disintegranting (OD) times by addition of other common excipients.
Neusilin® has been rated as an excellent antacid in Japan and…
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Using twin-screw melt granulation to co-process mannitol and hydroxypropylcellulose
With the advent of continuous manufacturing, twin-screw melt granulation has attracted interest in the pharmaceutical industry as a method for co-processing excipients and developing new formulations. Twin-screw melt granulation relies on the heat and shear produced by the viscous and frictional…
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Formulation Strategies to Improve the Stability and Handling of Oral Solid Dosage Forms of Highly…
Highly hygroscopic pharmaceutical and nutraceutical solids are prone to significant changes in their physicochemical properties due to chemical degradation and/or solid-state transition, resulting in adverse effects on their therapeutic performances and shelf life. Moisture absorption also leads to…
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Formulation and Development of Paediatric Orally Disintegrating Carbamazepine Tablets
Carbamazepine is a medicine used to manage epilepsy and partial or tonic-clonic seizures. This study aimed at formulating and obtaining carbamazepine orodispersible tablets for paediatric use at a 50 mg dose, with a diameter not greater than 6 mm and a tablet weight of 80 mg, through a direct…
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The Effect of Cellulose Nanofibers on the Manufacturing of Mini-Tablets by Direct Powder Compression
Mini-tablets (MTs) contain a small amount of active pharmaceutical ingredients in one small tablet. MTs are advantageous because they can be fine-tuned according to the age and weight of pediatric patients and they are easy for children and the elderly to swallow. However, there are manufacturing…
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3D printing of bioactive materials for drug delivery applications
Introduction
Three-dimensional (3D) printing, also known as additive manufacturing (AM), is a modern technique/technology, which makes it possible to construct 3D objects from computer-aided design (CAD) digital models. This technology can be used in the progress of drug delivery systems, where…
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Hydroxypropyl cellulose/Polyvinylpyrrolidone Matrix Tablets Containing Ibuprofen: Infiltration,…
The current study aims to prepare the matrix tablet including polyvinylpyrrolidone (PVP), hydroxypropyl cellulose (HPC) and poorly water-soluble ibuprofen (IBU) and to investigate the effect of varying polymer compositions on infiltration of the aqueous medium, erosion kinetics, swelling and drug…
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Moisture Sorption by Polymeric Excipients Commonly Used in Amorphous Solid Dispersions and its…
Moisture sorption by polymeric carriers used for the development of amorphous solid dispersions (ASDs) plays a critical role in the physical stability of dispersed drugs since moisture may decrease glass transition temperature (Tg) and thereby increase molecular mobility of drugs leading to their…
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Orally Dispersible Dosage Forms for Paediatric Use: Current Knowledge and Development of…
The paediatric population has always suffered from a lack of medicines tailored to their needs, especially in terms of accurate dosage, stability and acceptability. Orodispersible dosage forms have gone through a resurrection as an alternative to liquid formulations or fractioned solid formulations,…
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The Use of Sodium Alginate in Extended Release Tablet Formulations
Extended release tablets are commonly based on partially synthetic cellulose ethers, such as hypromellose (HPMC), hydroxyethyl cellulose (HEC), or hydroxypropyl cellulose (HPC). Alginates offer an interesting, all-natural alternative to these polymers. The aim of the present study was to…
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