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HPC – hydroxypropyl cellulose
Enhanced Oral Bioavailability of MT-102, a New Anti-inflammatory Agent, via a Ternary Solid…
This study aimed to develop a solid dispersion (SD) of MT-102, a new anti-inflammatory agent, to improve its oral bioavailability. The ternary SD formulations of MT-102 (a poorly soluble extract of Isatis indigotica and Juglans mandshurica) were prepared using a solvent evaporation method with…
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Novel Esomeprazole Magnesium-Loaded Dual-Release Mini-Tablet Polycap: Formulation, Optimization,…
Esomeprazole magnesium (EMP) is a proton pump inhibitor (PPI) that reduces acid secretion. EMP has a short plasma half-life (approximately 1.3 h); hence, nocturnal acid breakthrough (NAB) frequently occurs, disturbing the patient’s nighttime comfort and sleep. We aimed to develop a novel…
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Downstream Processing of Itraconazole:HPMCAS Amorphous Solid Dispersion: From Hot-Melt Extrudate to…
The downstream processing of hot-melt extruded amorphous solid dispersions (ASDs) into tablets is challenging due to the low tabletability of milled ASDs. Typically, the extrudate strand is sized before milling, as the strand cannot be fed directly into the milling system. At the lab scale, the…
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Formulation development of loratadine immediate-release tablets using hot-melt extrusion and 3D…
The main goal of this study was to develop immediate release Fused Deposition Modeling (FDM) 3D printed loratadine tablets using hot-melt extrusion (HME) filaments. Loratadine was used as a model drug with 10% (w/w) drug loading. Ten different formulations were prepared using Crospovidone and…
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Manufacture of Tablets with Structurally-Controlled Drug Release using Rapid Tooling Injection…
With advancements in the pharmaceutical industry pushing more towards tailored medicines, novel approaches to tablet manufacture are in high demand. One of the main drivers towards micro-scale batch production is the ability to fine-tune drug release. This study demonstrates the use of rapid tooling…
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Data-driven approach to mitigate quality impact of hygroscopic pharmaceutical raw materials…
The challenges of working with hygroscopic pharmaceutical raw materials can have a significant impact on the industry’s ability to make high-quality medicines. In order to mitigate the impact to the manufacturing process or product quality it is critical to understand the hygroscopicity of the raw…
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Method Development Technology and Optimisation Studies in Famotidine Pellets: An In Vitro Release
Oral medication administration has long been the most convenient and widely utilized technique of drug administration. Pellets are fine powders or granules of bulk pharmaceuticals and excipients agglomerated together. They are made up of tiny, freeflowing spherical or semi-spherical solid units that…
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Quality by design-based optimization of formulation parameters to develop quercetin nanosuspension…
The present study describes the formulation, optimization and characterization of quercetin loaded nanosuspension. The formulation was prepared using liquid antisolvent precipitation technique. Optimization of formulation was done using Box Behnken design by varying the concentration of sodium…
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Rheological Analysis of L-HPC and Suitability for Continuous Manufacturing
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could share their work in addition online with the Pharma Excipients…
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Assessment of the Extrusion Process and Printability of Suspension-Type Drug-Loaded AffinisolTM…
Three-dimensional (3D) printing technology enables the design of new drug delivery systems for personalised medicine. Polymers that can be molten are needed to obtain extruded filaments for Fused Deposition Modelling (FDM), one of the most frequently employed techniques for 3D printing. The aim of…
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