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HPMC – Hydroxypropylmethylcellulose
Inkjet Printing of Pharmaceuticals
Inkjet printing (IJP) is an additive manufacturing process that selectively deposits ink materials, layer-by-layer, to create three-dimensional (3D) objects or two-dimensional (2D) patterns with precise control over their structure and composition. This technology has emerged as an attractive and…
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Supercritical antisolvent-fluidized bed for the preparation of dry powder inhaler for pulmonary…
The supercritical antisolvent-fluidized bed coating process (SAS-FB) shows great potential as a technique to manufacture dry powder inhaler (DPI) that incorporate nanodrugs onto micronized matrix particles, capitalizing on the merits of both nanoparticle and pulmonary delivery. In this study,…
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Exploring the Potential of pH-Sensitive Polymers in Targeted Drug Delivery
The pH-sensitive polymers have attained significant attention in the arena of targeted drug delivery (TDD) because of their exceptional capability to respond to alteration in pH in various physiological environments. This attribute aids pH-sensitive polymers to act as smart carriers for therapeutic…
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Optimisation of the Manufacturing Process of Organic-Solvent-Free Omeprazole Enteric Pellets for the…
Abstract
Liquid formulations are mostly used in the paediatric population. However, with certain active pharmaceutical ingredients (APIs), it is very difficult to guarantee quality and stability; this is the case, for example, with omeprazole. Omeprazole is used as a model drug due to the lack of a…
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Determination of Gastric Water Emptying in Fasted and Fed State Conditions Using a…
Abstract
Because of the importance of gastric emptying for pharmacokinetics, numerous methods have been developed for its determination. One of the methods is the salivary tracer technique, which utilizes an ice capsule containing caffeine as a salivary tracer. Despite the ice capsule’s advantage…
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Exploring Applications of Plant-Derived Polymers in Fused Deposition Modeling of Oral Pharmaceutical…
Introduction
Additive manufacturing or 3D printing technology refers to the fabrication of three-dimensional objects from computer-aided designs (CAD) by adding layers of material on top of each other successively. In oral pharmacotherapy, this technology presents a paradigm shift from the current…
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MeltSerts Technology (Brinzolamide ocular inserts via hot-melt extrusion): QbD-steered development,…
The research work aimed to develop a robust sustained release biocompatible brinzolamide (BRZ)-loaded ocular inserts (MeltSerts) using hot-melt extrusion technology with enhanced solubility for glaucoma management. A 32 rotatable central composite design was employed for the optimization of the…
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The Impact of Polymer Mixture Composition on the Properties of Electrospun Membranes for Drug…
Orally dispersible films (ODFs) prepared by an electrospinning are a novel type of pharmaceutical formulation. This dosage form has the potential to be beneficial for small children and the elderly, who can have problems with administration of classical tablets due to the increased risk of choking…
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Design, Development, Evaluation, and In Vivo Performance of Buccal Films Embedded with…
Abstract
The therapeutic effectiveness of paliperidone in the treatment of schizophrenia has been limited by its poor oral bioavailability; hence, an alternative route could be appropriate. This study investigates the feasibility of developing a buccal film impregnated with paliperidone-loaded…
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Scale-up in Twin-screw wet granulation: Impact of formulation properties
The focus of this study was to investigate the sensitivity of different drug formulations to differences in process parameters based on previously developed scale-up strategies. Three different formulations were used for scale-up experiments from a QbCon® 1 with a screw diameter of 16 mm and a…
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