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HPMC – Hydroxypropylmethylcellulose
Formulation Development, Optimization, and Characterization of Entrectinib-Loaded Supersaturable…
Entrectinib is a novel potent anticancer drug with poor aqueous solubility. A supersaturable self-nanoemulsifying drug delivery system of entrectinib is developed using a super saturation promoter. The components of the isotropic mixture of SNEDDS were selected based on solubility and emulsification…
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In Vitro and In Vivo Characterization of the Transdermal Gel Formulation of Desloratadine for…
Chronic use of antihistamines can induce abnormalities in lipid absorption with potential excessive accumulation of lipids in the mesentery that can lead to the development of obesity and a metabolic syndrome. The focus of the present work was to develop a transdermal gel formulation of…
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Inclusion Complex of Ibuprofen-β-Cyclodextrin Incorporated in Gel for Mucosal Delivery: Optimization…
β-Cyclodextrin/ibuprofen inclusion complex was synthesized by freeze-drying method and characterized for phase solubility profiles, infrared spectra, thermal analysis, and X-ray powder diffractograms. The inclusion complex with HP-β-CD, as confirmed by molecular dynamics simulations, enhanced the…
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A double-layered gastric floating tablet for zero-order controlled release of dihydromyricetin:…
Dihydromyricetin (DHM) is an important natural flavonoid. However, most of DHM preparations have shown shortcomings such as low drug loading, poor drug stability, and/or large fluctuations in blood concentration. This study aimed to develop a gastric floating tablet with a double-layered structure…
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Twin-screw continuous mixing: Effect of mixing elements and processing parameters on properties of…
Twin-screw continuous mixing was used to prepare aerosol powders containing 1% budesonide, 0.3% magnesium stearate, and 98.7% α-lactose monohydrate. The effect of mixing configuration was studied using three screw profiles containing either a combing element, 30° forward kneading element, or a 60° …
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Texture analysis – a versatile tool for pharmaceutical evaluation of solid oral dosage forms
In the past few decades, texture analysis (TA) has gained importance as a valuable method for the characterization of solid oral dosage forms. As a result, an increasing number of scientific publications describe the textural methods that evaluate the extremely diverse category of solid…
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A dynamic model of tablet film coating processes for control system design
Aqueous film coating is a common and important step in the production of most pharmaceutical tablets. Controlling this process is beneficial to maintain stable and optimal operation and the use of a model capable of describing its main physical phenomena is fundamental for control system design.…
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Electrospun HPMC/PEO-blend orodispersible films: how slight batch differences affect the crucial…
Orodispersible films comprise a promising dosage form with a wide range of advantages compared to conventional formulations. The electrospinning process can significantly enhance the relevant characteristics of orodispersible films, e.g., the dissolution rate and the ease of administration. This…
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A review on the colours, flavours and shapes used in paediatric 3D printed oral solid dosage forms
Abstract
Objectives
This review aims at gleaning the currently available research reports that relate to 3D printlets for paediatric patients, and especially the excipients used to produce various colours, flavours, shapes and sizes.
Methods
A thorough literature review on paediatric 3D printed…
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Spray drying and nano spray drying as manufacturing methods of drug-loaded polymeric particles
In this review, benefits and drawbacks of the process of spray drying and nano spray drying with regard to the manufacturing of polymeric particles for pharmaceutical applications are discussed. Spray drying has been used for many years in the food, chemical and pharmaceutical industries for…
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