HPMC – Hydroxypropylmethylcellulose

Abstract Background: Prasugrel is a member of thienopyridine class of ADP receptors that reduce the aggregation ("Clumping") of platelets by irreversibly binding to P2Y12 receptors. Objective: The aim of this study is to develop new formulation of Prasugrel tablets by direct compression…
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This study aims to optimize the concentrations of hydroxypropyl methyl cellulose (HPMC) K4M and Eudragit L100- 55 (methacrylic acid) in formulation of extended-release tablets containing guanfacine hydrochloride by employing a 32 -factorial design approach. Extended-release tablets of guanfacine…
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SEE PEARLITOL® CR-H Roquette´s new, industry-first mannitol and hydroxypropyl methylcellulose (HPMC) blend, designed for controlled release drug formulation. Leave behind wet granulation, lengthy drying times and limited flowability and unlock the potential of direct compression to create…
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Liposome, as a drug delivery vehicle, entraps drugs, releases them sustainably, and modifies release patterns. This entrapment has diminished exposure of the drug to the eye medium, which could minimize adverse effects. In this investigation, 18 formulations in 3 key categories (liposome, gel and…
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Given their safety and efficiency in protecting protein integrity, polysorbates (PSs) have been the most widely used excipients for the stabilization of protein therapeutics for years. In recent decades, however, there have been numerous reports about visible or sub-visible particles in…
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Three-dimensional printing (3DP) technology enables an important improvement in the design of new drug delivery systems, such as gastroretentive floating tablets. These systems show a better temporal and spatial control of the drug release and can be customized based on individual therapeutic needs.…
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Hydroxypropyl methylcellulose (HPMC) is an important polymeric excipient. Its versatility in terms of molecular weights and viscosity grades is the basis for its wide and successful application in the pharmaceutical industry. Low viscosity grades of HPMC (like E3 and E5) have been used as physical…
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The direct tailoring of the size, composition, or number of layers belongs to the advantages of 3D printing employment in producing orodispersible films (ODFs) compared to the frequently utilized solvent casting method. This study aimed to produce porous ODFs as a substrate for medicated ink…
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The study aims to investigate the ability of lyophilized nasal inserts of nanosized atomoxetine HCl solid lipid nanoparticles (ATM-SLNs) to transport atomoxetine (ATM) directly to the brain and overcome the first-pass metabolism. In this case, 16 formulae of (ATM-SLNs) were prepared using hot melt…
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The powder flowability of active pharmaceutical ingredients and excipients is a key parameter in the manufacturing of solid dosage forms used to inform the choice of tabletting methods. Direct compression is the favoured tabletting method; however, it is only suitable for materials that do not show…
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