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HPMC – Hydroxypropylmethylcellulose
Mucoadhesive drug delivery systems: a promising noninvasive approach to bioavailability enhancement.…
Abstract
Introduction
Mucoadhesive drug delivery systems (MDDS) are specifically designed to interact and bind to the mucosal layer of the epithelium for localized, prolonged, and/or targeted drug delivery. Over the past 4 decades, several dosage forms have been developed for localized as…
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The Use of Calcium Phosphate-Based Starter Pellets for the Preparation of Sprinkle IR MUPS…
Sprinkle formulations represent an interesting concept of medicinal products aimed at the steadily growing population of patients suffering from swallowing difficulties (dysphagia). In the present work, immediate-release sprinkle MUPS (multiple-unit pellet system) containing rosuvastatin calcium as…
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Numerical Investigation of the Particle Dynamics in a Rotorgranulator Depending on the Properties of…
In the pharmaceutical industry, the coating of particles is a widely used technique to obtain desired surface modifications of the final product, e.g., controlled release of the active agents. The production of round, coated particles is particularly important, which is why fluidized bed rotor…
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Development of an Oral Liquid Formulation of Nicardipine Hydrochloride Compounded with Simple…
Nicardipine hydrochloride is an anti-hypertensive drug that is used off-label to treat hypertension in children. A previous oral formulation of nicardipine hydrochloride was developed using a commercial vehicle as an excipient. However, ready-to-use vehicles are prone to supply shortages, and their…
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Use of polyvinyl alcohol (PVA) to overcome challenges in ophthalmic formulations
Successful ophthalmic drug formulations rely on the selection of the correct polymer to ensure the desired characteristics such as retention in the eye cavity and solubility. One example of such an excipient is polyvinyl alcohol (PVA) which offers many advantages for ophthalmic drug formulations…
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Interpretable artificial neural networks for retrospective QbD of pharmaceutical tablet…
As the pharmaceutical industry increasingly adopts the Pharma 4.0. concept, there is a growing need to effectively predict the product quality based on manufacturing or in-process data. Although artificial neural networks (ANNs) have emerged as powerful tools in data-rich environments, their…
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Formulation, development and characterization of ibuprofen microemulgel for arthritis
Objective: Microemulgel is composed of aqueous phase, lipophilic phase, along with surfactant and co-surfactant, a suitable gelling agent is also incorporated. The drug Ibuprofen is non-steroidal anti-inflammatory drug. Its oral administration associated with many GIT, hepatic and renal problems.…
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Avoiding N-nitrosodimethylamine formation in metformin pharmaceuticals by limiting dimethylamine and…
Since late 2019, concerns regarding trace levels of the probable human carcinogen N-dimethylnitrosamine (NDMA) in Metformin-containing pharmaceuticals have been an issue if they exceeded the maximum allowable intake of 96 ng/day for a medicine with long-term intake. Here, we report results from an…
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Tackling the Trends – How Excipient Technologies Enable Oral Solid Innovation
Did you know that between 2015 and 2019, 70% to 80% of new molecular entities (NMEs) approved by the FDA were small molecules, and, in 2019, 68% of small molecules approved were oral dosage delivery?
Although drug delivery innovations in other areas may receive more excitement and coverage, for…
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Development of multifunctional drug delivery system via hot-melt extrusion paired with fused…
The model of core–shell structured tablets is gaining increased interest due to its advantages in controlled-release and combinational drug delivery. Through the encapsulation of the drug by the outer shell, this model exhibits huge potential for reduced administration frequency, improved…
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