Browsing Category
HPMC – Hydroxypropylmethylcellulose
Atorvastatin-loaded emulsomes foam as a topical antifungal formulation
Dermal fungal infection faces many challenges, especially for immunocompromised patients. Recently, the repositioning of atorvastatin (ATO) as a promising anti-mycoses therapy is used to overcome some issues of conventional therapeutic agents such as microbial resistance. The goal of this study was…
Read More...
Read More...
Drug delivery to the targeted site of action in the human body is always affected by the excipients used and almost in the same manner by some processing variables like changes in the compression force. The aim of this study was to investigate the impact of the changes in compression forces during…
Read More...
Read More...
Formulation development and evaluation of Transdermal patch of Astaxanthin
Transdermal patches are the cutting-edge drug delivery approach that may be utilized to bypass hepatic first-pass metabolism and to increase absorption for effective systemic effects. By using HPMC, Eudragit L-100, Plasticizer, and Permeation Enhancer in varying proportions, the Astaxanthin drug…
Read More...
Read More...
Formulation and Evaluation of Olmesartan Medoxomil Tablets
This work proposes a methodology for the design, development, and characterization of tablets prepared by the direct compression method of olmesartan medoxomil. The main objective was to ensure a high dissolution rate of the active ingredient. Therefore, a rigorous selection of excipients was…
Read More...
Read More...
Processing of Lipid Nanodispersions into Solid Powders by Spray Drying
Spray drying is a promising technology for drying lipid nanodispersions. These formulations can serve as carrier systems for poorly water-soluble active pharmaceutical ingredients (APIs) that are loaded into the lipid matrix to improve their bioavailability. Once the API-loaded nanocarriers have…
Read More...
Read More...
Buccal films: A review of therapeutic opportunities, formulations & relevant evaluation…
The potential of the mucoadhesive film technology is hard to ignore, owing to perceived superior patient acceptability versus buccal tablets, and significant therapeutic opportunities compared to conventional oral drug delivery systems, especially for those who suffer from dysphagia. In spite of…
Read More...
Read More...
Commercially Available Enteric Empty Hard Capsules, Production Technology and Application
Currently, there is a growing need to prepare small batches of enteric capsules for individual therapy or clinical evaluation since many acidic-sensitive substances should be protected from the stomach’s acidic environment, including probiotics or fecal material, in the fecal microbiota…
Read More...
Read More...
A New Method to Determine Drug-Polymer Solubility Through Enthalpy of Melting and Mixing
In this study, a new method to determine the solubility of crystalline drugs in (amorphous) polymers is proposed. The method utilizes annealing of supersaturated amorphous solid dispersions to achieve equilibrium between dissolved and recrystallized drug. By measuring the enthalpy of melting and…
Read More...
Read More...
Multivariate Data Analysis and Central Composite Design-Oriented Optimization of Solid Carriers for…
The study was initiated with two major purposes: investigating the role of isomalt (GIQ9) as a pharmaceutical carrier for solid self-nanoemulsifying drug delivery systems (S-SNEDDSs) and improving the oral bioavailability of lipophilic curcumin (CUN). GIQ9 has never been explored for solidification…
Read More...
Read More...
CPHI 2022: Roquette Launches Next-Generation Direct Compression Solutions – PEARLITOL® CR-H Mannitol…
La Madeleine, France – October 31, 2022.
Roquette, a global leader in plant-based ingredients and a leading provider of pharmaceutical and nutraceutical excipients, today announces the launch of two next-generation mannitol products for direct compression – PEARLITOL® CR-H and PEARLITOL® 200 GT.…
Read More...
Read More...