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HPMC – Hydroxypropylmethylcellulose
Three-Dimensional Printing of a Container Tablet: A New Paradigm for Multi-Drug-Containing Bioactive…
This research demonstrates the use of fused deposition modeling (FDM) 3D printing to control the delivery of multiple drugs containing bioactive self-nano emulsifying drug-delivery systems (SNEDDSs). Around two-thirds of the new chemical entities being introduced in the market are associated with…
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Incorporation of itraconazole nano-co-crystals into multiparticulate oral dosage forms
Limited research has been performed on the downstream processing of nano-co-crystal suspensions into solid oral dosage forms. The objectives of this study were to evaluate the impact of three downstream processes (wet granulation, spray granulation and bead layering) on the performance of…
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Influence of In Situ Calcium Pectinate Coating on Metoprolol Tartrate Pellets for Controlled Release…
In situ calcium pectinate-coated pellets were proposed by applying an alternate coating method to drug-layered pellets to achieve colon-specific drug delivery. Solution layering of metroprolol tartrate, a water-soluble model drug, on inert core pellets was achieved using a centrifugal granulator…
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Oral Thin-films from Design to Delivery: A Pharmaceutical Viewpoint
Stable drug-type tablets and capsules are painful to drink or chew for many pediatric and geriatric patients. Accurate dosing is also an issue for liquid orals (syrup, suspension, emulsion, and so on). Several fast-dissolving drug delivery systems have been designed to address these issues. One of…
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Integrated Purification and Formulation of an Active Pharmaceutical Ingredient via Agitated Bed…
Integrated API and drug product processing enable molecules with high clinical efficacy but poor physicochemical characteristics to be commercialized by direct co-processing with excipients to produce advanced multicomponent intermediates. Furthermore, developing isolation-free frameworks would…
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Spray dried powders for nasal delivery: Process and formulation considerations
Powders for nasal delivery have been recognized as advantageous dosage forms over liquids due to increased stability and residence time on nasal mucosa, with improved bioavailability. They can be manufactured by spray-drying, allowing the optimization of the particle properties that are critical to…
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Semi-solid extrusion 3D printing of tailored ChewTs for veterinary use – A focus on…
Currently, there are a few or none marketed gabapentin veterinary products, leading to treatment with compounded dosage forms or off-label use of human-marketed products. With the said approaches, there are significant risks of preparation errors, rendering these practices suboptimal. A new…
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High-amylose maize starch as a novel film former to develop oral films with excellent mechanical…
Aim: The study involved the development and optimization of the fast-dissolving oral films of salbutamol sulfate using high-amylose maize starch (HAMS) as a novel film former by comparison with the HPMC E50 (hydroxy propyl methyl cellulose) films. The high aqueous solubility, low dose, and low…
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Development, In-Vitro and Ex-Vivo Evaluation of Muco-Adhesive Buccal Tablets Of Hydralazine…
Hydralazine hydrochloride is an anti-hypertensive drug. The drug has poor oral bioavailability (BA) of about 30- 50% due to extensive first-pass metabolism. Hence, the buccal delivery was used to enhance the BA of hydralazine hydrochloride. Buccal muco-adhesive tablets were prepared by direct…
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Quality by design-based optimization of formulation parameters to develop quercetin nanosuspension…
The present study describes the formulation, optimization and characterization of quercetin loaded nanosuspension. The formulation was prepared using liquid antisolvent precipitation technique. Optimization of formulation was done using Box Behnken design by varying the concentration of sodium…
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