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HPMC – Hydroxypropylmethylcellulose
Formulation and Evaluation of Transdermal Gel Containing Tacrolimus-Loaded Spanlastics: In Vitro, Ex…
Our goal was to prepare Span 60-based elastic nanovesicles (spanlastics (SPLs)) of tacrolimus (TCR) using the adapted ethanol injection method, characterize them, and evaluate their ability to improve the transdermal permeation of the active substance. The impact of two different concentrations of…
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An Enhanced Stacking Ensemble Method for Granule Moisture Prediction in Fluidized Bed Granulation
Moisture is a crucial quality property for granules in fluidized bed granulation (FBG) and accurate prediction of the granule moisture is significant for decision making. This study proposed a novel stacking ensemble method to predict the granule moisture based on granulation process parameters. The…
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Formulation and in-vitro evaluation of Bosewellia Serrata extract loaded transferosomal gel for…
Objective:
The main objective of the current research work was to formulate and evaluate Bosewellia serrata extract loaded transferosomal topical gels. To overcome the drawbacks associated with oral administration of Bosewellia serrata extract in Osteoarthritis treatment.
Methodology:…
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The Impact of the Lamination Pressure on the Properties of Electrospinned Nanofibrous Films
The purpose of this work is to explore the preparation of nanofibrous orally dispersible films (ODFs) by needleless electrospinning from the active pharmaceutical ingredient (API) Tadalafil using particles suspended in a solution of polymers and other excipients. The prepared films were…
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Towards a better understanding of the role of stabilizers in QESD crystallizations
Quasi-emulsion solvent-diffusion crystallization (QESD) is a type of spherical crystallization which can be used as a particle design method to improve the flowability and micromeritic properties of drugs or excipients. Spherical particles are generated by dispersing a solvent phase in an…
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Effects of polymer addition on the non-strongly interacting binary co-amorphous system…
Co-amorphous systems have been developed to address the solubility challenge of poorly water-soluble crystalline drugs. However, due to the thermodynamic instability of amorphous forms, amorphization may result in recrystallization during manufacturing, storage, or dissolution, which is one of the…
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Advances in oral peptide drug nanoparticles for diabetes mellitus treatment
Peptide drugs play an important role in diabetes mellitus treatment. Oral administration of peptide drugs is a promising strategy for diabetes mellitus because of its convenience and high patient compliance compared to parenteral administration routes. However, there are a series of formidable…
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Fused deposition modeling three-dimensional printing of flexible polyurethane intravaginal rings…
We designed and engineered novel intravaginal ring (IVR) medical devices via fused deposition modeling (FDM) three-dimensional (3D) printing for controlled delivery of hydroxychloroquine, IgG, gp120 fragment (encompassing the CD4 binding site), and coumarin 6 PLGA-PEG nanoparticles (C6NP). The…
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Blind-Watermarking – Proof-of-Concept of a Novel Approach to Ensure Batch Traceability for 3D…
Falsified medicines are a major issue and a threat around the world. Various approaches are currently being investigated to mitigate the threat. In this study, a concept is tested that encodes binary digits (bits) on the surface of Fused Deposition Modelling (FDM) 3D printed geometries. All that is…
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Design, Preparation and In Vitro Evaluation of Core–Shell Fused Deposition Modelling 3D-Printed…
The aim of the study was to investigate core–shell pulsatile tablets by combining the advantages of FDM 3D printing and traditional pharmaceutical technology, which are suitable for a patient’s individual medication and chronopathology. The tablets were designed and prepared with the commercial…
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