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HPMC – Hydroxypropylmethylcellulose
‘Tablet-in-Syringe’: A Novel Dosing Mechanism for Dysphagic Patients Containing Fast-Disintegrating…
With the ability to fabricate personalized dosage forms and considerably shorter manufacturing time, semisolid extrusion (SSE) 3D printing has rapidly grown in popularity in recent years as a novel, versatile manufacturing method that powers a wide range of applications in the pharmaceutical field.…
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Hydroxypropyl-β-Cyclodextrin Enhances Oral Absorption of Silymarin Nanoparticles Prepared Using…
The oral bioavailability of drugs is limited by factors such as poor membrane permeability, low solubility, and low dissolution rate. Silymarin (SLM) is a health-food active ingredient that is good for immunosuppression and tumor suppression. However, obtaining a good oral bioavailability is…
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Tailoring Chlorthalidone Aqueous Solubility by Cocrystallization: Stability and Dissolution Behavior…
A cocrystal of the antihypertensive drug chlorthalidone (CTD) with caffeine (CAF) was obtained (CTD-CAF) by the slurry method, for which a 2:1 stoichiometric ratio was found by powder and single-crystal X-ray diffraction analysis. Cocrystal CTD-CAF showed a supramolecular organization in which CAF…
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FDM 3D-Printed Sustained-Release Gastric-Floating Verapamil Hydrochloride Formulations with…
The aim of this work was to design and fabricate fused deposition modeling (FDM) 3D-printed sustained-release gastric-floating formulations with different shapes (cylinder, capsule and hemisphere) and infill percentages (0% and 15%), and to investigate the influence of shape and infill percentage on…
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Concept of Orodispersible or Mucoadhesive “Tandem Films” and Their Pharmaceutical Realization
Orodispersible or mucoadhesive films as a patient-oriented dosage form for low-dosed drugs are usually produced using solvent casting. This paper presents a modification of the solvent casting technique that aimed to divide oral films into two or more compartments.
The proposed objectives and…
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Sampling and diversion strategy for twin-screw granulation lines using batch statistical process…
Continuous manufacturing is now considered as a well-established technique by pharmaceutical companies. However, the limited number of filed applications reflects the complexity to translate a science that has been described in many publications to an actual drug product. Process stability…
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Experience the future of Titanium Dioxide replacement: VIVACOAT® free
Discover bright white films and brilliant colors at reasonable weight gains even on your darkest tablet cores!
Enjoy the freedom of choice when banning TiO2 from your tablet coatings:
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In-Depth Understanding of Granule Compression Behavior under Variable Raw Material and Processing…
Tablet manufacturing involves the processing of raw materials through several unit operations. Thus, the mitigation of input-induced variability should also consider the downstream processability of intermediary products. The objective of the present work was to study the effect of variable raw…
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The Effect of Binder Types on the Breakage and Drying Behavior of Granules in a Semi-Continuous…
Current study investigated the effect of different binder types on the granule drying process and the granule breakage behavior in a semi-continuous fluid bed dryer integrated in the C25 ConsiGma-system. The studied binders (i.e. hydroxypropyl pea starch, hydroxypropyl methylcellulose E15,…
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Management and control of intraocular pressure applying macitentan hydrogel film formulation:…
Background
Macitentan blocks endothelin receptors in order to control the pulmonary arterial hypertension (PAH). Oral administration of macitentan is associated with painful urination and troubled breathing.
Objectives
Formulated macitentan hydrogel film was used for examining the control of…
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