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HPMC – Hydroxypropylmethylcellulose
Exploration of Neusilin® US2 as an Acceptable Filler in HPMC Matrix Systems—Comparison of…
Modern pharmaceutical technology still seeks new excipients and investigates the further use in already known ones. An example is magnesium aluminometasilicate Neusilin® US2 (NEU), a commonly used inert filler with unique properties that are usable in various pharmaceutical fields of interest. We…
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Application of a novel electrostatic dry powder coating technology on capsules for enteric release
Dry coating of pharmaceutical dosages represents the future of functional coating given its environmental friendliness and cost effectiveness. Based on the electrostatic dry powder coating technology developed by our group, hard gelatin capsules and HPMC capsules were successfully coated for the…
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Comparison of Hydroxypropylcellulose and Hot-Melt Extrudable Hypromellose in Twin-Screw Melt…
High-molecular-weight hypromellose (HPMC) and hydroxypropyl cellulose (HPC) are widely known, extended-release polymers. Conventional high-molecular-weight HPMCs are preferred in extended-release applications but not widely used in twin-screw melt granulation due to processability difficulties at…
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3D-Printed Coating of Extended-Release Matrix Tablets Effective Tool for Prevention of…
Tablets used for extended drug release commonly contain large amounts of drugs. The corresponding drug release mechanism thus has to be well-known and invariable under numerous conditions in order to prevent any uncontrolled drug release. Particularly important is the stability and invariability of…
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Control Strategy for Process Development of High-Shear Wet Granulation and Roller Compaction to…
In this study, we developed a control strategy for a drug product prepared by high-shear wet granulation and roller compaction using integrated quality by design (QbD). During the first and second stages, we optimized the process parameters through the design of experiments and identified the…
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The Effect of Capsule-in-Capsule Combinations on In Vivo Disintegration in Human Volunteers: A…
Controlling the time point and site of the release of active ingredients within the gastrointestinal tract after administration of oral delivery systems is still a challenge. In this study, the effect of the combination of small capsules (size 3) and large capsules (size 00) on the disintegration…
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Understanding the Effect of Energy Density and Formulation Factors on the Printability and…
Selective laser sintering (SLS) is a rapid prototyping technique for the production of three-dimensional objects through selectively sintering powder-based layer materials. The aim of the study was to investigate the effect of energy density (ED) and formulation factors on the printability and…
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Quantification of Compatibility Between Polymeric Excipients and Atenolol Using Principal Component…
An important challenge to overcome in the solid dosage forms technology is the selection of the most biopharmaceutically efficient polymeric excipients. The excipients can be selected, among others, by compatibility studies since incompatibilities between ingredients of the drug formulations…
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Clinical Demonstrations of Controlled-Release Tablets Constructed by the Combined Usage of Shellac…
A new tablet system was examined for an intestinal delivery system using hydroxypropyl methylcellulose (HPMC) and shellac. HPMC was incorporated into the inside of the tablet, and shellac was coated on the surface, which was evaluated for its controlled-release property through several dissolution…
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Cyclodextrin as Functional Carrier in Development of Mucoadhesive Tablets Containing Polygoni…
Polygoni cuspidati root is a resveratrol-rich source with anti-inflammatory, angiogenic and neuroprotective effects. The raw material was standardized for the content of resveratrol, for which there is a special justification for administration within the oral mucosa. To improve the solubility of…
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