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HPMC – Hydroxypropylmethylcellulose
Binder jetting 3D printing of challenging medicines: from low dose tablets to hydrophobic molecules
Increasing access to additive manufacturing technologies utilising easily available desktop devices opened novel ways for formulation of personalized medicines. It is, however, challenging to propose a flexible and robust formulation platform which can be used for fabrication of tailored solid…
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Data-Enriched Edible Pharmaceuticals (DEEP) with Bespoke Design, Dose and Drug Release
Data-enriched edible pharmaceuticals (DEEP) is an approach to obtain personalized medicine, in terms of flexible and precise drug doses, while at the same time containing data, embedded in quick response (QR) codes at a single dosage unit level. The aim of this study was to fabricate DEEP with a…
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Development of a Scalable Process of Film-Coated bi-Layer Tablet Containing Sustained-Release…
The development of new drugs that combine active ingredients for the treatment hypertension is critically essential owing to its offering advantages for both patients and manufacturers. In this study, for the first time, detailed development of a scalable process of film-coated bi-layer tablets…
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The evaluation of the effect of different superdisintegrants on the drug release from FDM 3D printed…
Paracetamol-loaded tablets were printed by fused deposition modelling technique, using polyvinyl alcohol as a backbone polymer and Affinisol™ HPMC as a plasticizer in all formulations. Four different strategies were applied in order to accelerate the drug release from the tablets. First, different…
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Development of buccal film formulations and their mucoadhesive performance in biomimetic models
When developing buccal films for oromucosal drug administration, adhesion is essential to ensure sufficient time for permeation of the active ingredient(s) through the oral mucosa and avoid the detachment and subsequent swallowing of the film. In this study, biomimetic materials were evaluated as a…
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Oral colon delivery platform based on a novel combination approach: Design concept and preliminary…
An oral colon delivery platform based on a novel combination strategy, leveraging multiple physiological characteristics of the intestine, is proposed. The system comprises a drug core, a water-swellable/soluble inner layer based on a hydrophilic cellulose derivative and an enteric outer layer…
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Development of Mucoadhesive Film-Forming Systems Containing Black Ginger Extract for Aphthous Ulcers
Film-forming systems (FFSs) were developed by using Eudragit® E100 as a film former. Kaempferia parviflora (black ginger) extract was used as an anti-inflammatory agent for aphthous ulcers. The FFS could rapidly form a thin film in only 5 s when it was applied to a wet surface e.g. an aphthous…
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Preparation of Carbopol 934 Based Ketorolac Tromethamine Buccal Mucoadhesive Film: In Vitro, Ex…
The goal of present investigation was to formulate and evaluate ketorolac tromethamine (KTM) mucoadhesive buccal films. The films were prepared by solvent evaporation method using PVP K30, HPMC K4M, HPMC K15M, carbopol 934, chitosan, and sodium alginate as polymers and propylene glycol as…
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Understanding Direct Powder Extrusion for Fabrication of 3D Printed Personalised Medicines: A Case…
Fuse deposition modelling (FDM) has emerged as a novel technology for manufacturing 3D printed medicines. However, it is a two-step process requiring the fabrication of filaments using a hot melt extruder with suitable properties prior to printing taking place, which can be a rate-limiting step in…
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Enhance the solubility of poorly soluble drugs with AFFINISOL™
Looking to enhance the solubility of poorly soluble drugs?
Consider AFFINISOL™, a water-soluble polymer that optimizes solubility enhancement by maintaining stable solid dispersions and inhibiting API crystallization.
It’s been specifically designed for generating solid dispersions via…
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