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HPMC – Hydroxypropylmethylcellulose
Quantitative characterisation of extended release tablets with quetiapine using NIR chemometric…
This study aims to develop and validate NIR-chemometric methods for quantifying the API (quetiapine) and two excipients in extended-release tablets without sample preparation. The calibration samples were prepared following an experimental design with three variables (quetiapine, HPMC and…
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Investigation on Formulation Strategies to Mitigate Compression-Induced Destabilization in…
Compression-induced destabilization was investigated in various celecoxib amorphous solid dispersions containing hydroxypropyl methylcellulose (HPMC), poly(vinylpyrrolidone)/vinyl acetate copolymer (PVP/VA), or poly(vinylpyrrolidone) (PVP) at a concentration range of 1–10% w/w. Pharmaceutically…
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Formulation development and in-vitro evaluation of dexlansoprazole loaded double walled microspheres
In the present work, double walled microspheres of Dexlansoprazole using Sodium alginate, HPMC E15, Xanthan gum, Ethyl cellulose as copolymers and along with Carbopol were formulated to deliver Dexlansoprazole through oral route. Details regarding the preparation and evaluation of the formulations…
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Exploring the unexpected behavior of HPMC matrix tablets in dissolution media with SDS
In the case of poorly soluble drugs, a surfactant is often added to dissolution media to increase drug release. In this study, diclofenac sodium (DF-Na) release from hydroxypropyl methylcellulose (HPMC) matrix tablets was explored in dissolution media containing different sodium lauryl sulfate (SDS)…
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Comparison of Three Different Aqueous Microenvironments for Enhancing Oral Bioavailability of…
Background: The purpose of this study was to screen various drug delivery systems for improving the aqueous solubility and oral bioavailability of sildenafil. Three representative techniques, solid self-nanoemulsifying drug delivery systems (SNEDDS), amorphous microspheres and crystalline…
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Effervescent floating matrix tablets of a novel anti-cancer drug neratinib for breast cancer…
The main purpose of this study was to develop a novel gastro-retentive drug delivery system via effervescent technique for the treatment of breast cancer. Neratinib (NTB) is a novel anticancer drug, poorly soluble at higher pH, was been used as a model drug and an attempt was made to develop a…
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Using a material database and data fusion method to accelerate the process model development of high…
High shear wet granulation (HSWG) has been wildly used in manufacturing of oral solid dosage (OSD) forms, and process modeling is vital to understanding and controlling this complex process. In this paper, data fusion and multivariate modeling technique were applied to develop a…
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Cellulase as an “active” excipient in prolonged-release HPMC matrices: a novel strategy towards…
Hydrophilic matrices are of utmost interest for oral prolonged release of drugs. However, they show decreasing release rate over time, mainly due to lengthening of the diffusional pathway across the gel formed upon glass-rubber transition of the polymer. Therefore, achievement of zero-order release…
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Lipid Based Formulations in Hard Gelatin and HPMC Capsules: A Physical Compatibility Study
Purpose
To investigate the compatibility between hard gelatin and HPMC capsules with a range of different isotropic lipid based formulations containing multiple excipients.
Methods
The miscibility was investigated for 350 systems applying five different oils (Labrafac ™ lipophile WL1349, Maisine®…
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3D Printed Intragastric Floating and Sustained-release Tablets with Air Chambers
This work aimed to use hot-melt extrusion (HME) and dual fused deposition modeling (FDM) 3D printing technology to develop a novel intragastric floating and sustained-release drug delivery system. The intragastric floating and sustained-release tablet was engineered by employing hydroxypropyl…
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