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HPMC – Hydroxypropylmethylcellulose
The Development of Floating Multiple Unit Mini Tablets of Bosentan Using QbD: Characterisation and…
Background: Multiple dosing is required for bosentan in order to achieve steady-state concentration. Hence formulating bosentan controlled release formulation could be an approach to solve this issue.
Objective: The objective is to develop floating multiple unit minitablets of bosentan using the…
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Role of release modifiers to modulate drug release from fused deposition modelling (FDM) 3D printed…
Although hot melt extrusion (HME) has been used in combination with fused deposition modelling (FDM) three-dimensional printing (3DP), suitable feedstock materials such as polymeric filaments with optimum properties are still limited. In this study, various release modifying excipients, namely,…
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Application of Design Space, Uncertainty, and Risk Profile Strategies to the Development and…
Background: Counterfeit medicines are an increasing scourge that are difficult to identify and they have become industrialized and widespread through highly organized illegal channels.
Objective: This research aims to develop a robust method to determine four phosphodiesterase type-5 inhibitors…
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Effects of humidity and glidants on the flowability of pharmaceutical excipients. An experimental…
Granular materials are part of the design, production and final products of different industrial sectors. Powder flowability is a major topic in manufacturing and transport as it is closely related to process feasibility. Nonetheless, the flows of granular materials are not easy to describe or…
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Structural and thermal analysis of cannabidiol orodispersible formulation
Cannabidiol (CBD) is an alkaloid that can be found in the Cannabis species, currently used in United States of America under the name of Epidiolex®, which was approved by Food and Drug Administration (FDA) for seizures treatment. The purpose of this study was to investigate the structural…
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Biopharmaceutical and rheometric studies in the development of a gel composition with dimethindene…
Every year there is an increase in the number of cases of hypersensitivity to bites from various insects. A local allergic reaction to bites occurs within a few minutes and is accompanied by acute pain at the site of the bite, severe itching, hyperemia, the appearance of papules, tissue edema, and…
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Nanostructured Valsartan Microparticles with Enhanced Bioavailability Produced by High-Throughput…
The high-throughput drying and encapsulation technique called electrospraying assisted by pressurized gas (EAPG) was used for the first time to produce nanostructured valsartan within microparticles of excipients. Valsartan, a poorly absorbed and lipid-soluble drug, was selected since it is…
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The Development of Thin-film Freezing and Its Application to Improve Delivery of Biologics as Dry…
While the formulation of pharmaceuticals as liquids is common practice, powders are associated with enhanced stability, avoidance of the cold chain, lower dosing requirements, and more convenient administration. These are particularly critical for proteins, as they are expensive and complicated to…
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Insights into the Control of Drug Release from Complex Immediate Release Formulations
The kinetics of water transport into tablets, and how it can be controlled by the formulation as well as the tablet microstructure, are of central importance in order to design and control the dissolution and drug release process, especially for immediate release tablets.
This research employed…
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Segmented intravaginal ring for the combination delivery of hydroxychloroquine and anti-CCR5 siRNA…
Vaginal drug delivery has been shown to be a promising strategy for the prevention of sexually transmitted infections. Therapy delivered at the site of infection has many advantages including improved therapeutic efficacy, reduction in systemic toxicity, and reduced potential for development of drug…
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