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HPMC – Hydroxypropylmethylcellulose
Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: an UNGAP…
The absorption of oral drugs is frequently plagued by significant variability with potentially serious therapeutic consequences. The source of variability can be traced back to interindividual variability in physiology, differences in special populations (age- and disease-dependent), drug and…
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Opportunities and challenges of three-dimensional printing technology in pharmaceutical formulation…
Three-dimensional printing (3D-printing) is a technology that prints the products layer-by-layer, in which materials are deposited according to the digital model designed by computer aided design (CAD) software. This technology has competitive advantages regarding product design complexity, product…
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3DP Printing of Oral Solid Formulations: A Systematic Review
Three-dimensional (3D) printing is a recent technology, which gives the possibility to manufacture personalised dosage forms and it has a broad range of applications. One of the most developed, it is the manufacture of oral solid dosage and the four 3DP techniques which have been more used for their…
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Microneedle for transdermal drug delivery: current trends and fabrication
Transdermal delivery has the advantage of bypassing the first-pass effect and allowing sustained release of the drug. However, the drug delivery is limited owing to the barrier created by the stratum corneum. Microneedles are a transdermal drug delivery system that is painless, less invasive, and…
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Development of gastro-resistant coated probiotic granulates and evaluation of viability and release…
Probiotics have become one of the most consumed food supplements worldwide. Many probiotic strains are sensitive to low pH and bile concentrations encountered in the gastrointestinal tract upon oral ingestion. This study aimed at developing gastro-resistant probiotic granulates releasing viable…
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Optimization of semisolid extrusion (pressure-assisted microsyringe)-based 3D printing process for…
3D printing of pharmaceutical formulations requires juggling between the material properties and the printing process to achieve the geometry of the 3D printed products with the desired dose and release. The purpose of the current investigation is to identify the material suitability for semisolid…
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Nanoemulsion-based patch for the dermal delivery of ascorbic acid
Photo-aging is caused mainly by sun radiations, which consist mainly of the ultraviolet radiation (UVA and UVB). Ascorbic acid (AA) has been widely used in the cosmetic field as an anti-wrinkle, anti-pigmentary, and antioxidant agents, however, its cosmetic application is limited due to its poor…
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Quality by Design Applied Development of Immediate-Release Rabeprazole Sodium Dry-Coated Tablet
The aim of this study was to develop immediate-release oral rabeprazole sodium tablets with rapid efficacy and gastric stability for the treatment of gastroesophageal reflux disease. Rabeprazole sodium is a commonly prescribed proton pump inhibitor; however, it is extremely unstable and degrades in…
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Two-dimensional moisture content and size measurement of pharmaceutical granules after fluid bed…
In pharmaceutical wet granulation, drying is a critical step in terms of energy and material consumption, whereas granule moisture content and size are important process outcomes that determine tabletting performance. The drying process is, however, very complex due to the multitude of interacting…
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Evaluation of Binders in Twin-Screw Wet Granulation
The binders povidone (Kollidon 30), copovidone (Kollidon VA64), hypromellose (Pharmacoat 606), and three types of hyprolose (HPC SSL‑SFP, HPC SSL, and HPC SL‑FP) were evaluated regarding their suitability in twin-screw wet granulation. Six mixtures of lactose and binder as well as lactose without…
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