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HPMC – Hydroxypropylmethylcellulose
Ternary Amorphous Solid Dispersions Containing a High-Viscosity Polymer and Mesoporous Silica…
The aim of this study was to evaluate the benefits of a ternary amorphous solid dispersion (ASD) that was designed as an immediate-release tablet with a high drug load (e.g., 40% w/w) to produce heightened maintenance of drug supersaturation during dissolution testing, which will be henceforth…
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Evaluation of Experimental Multi-Particulate Polymer-Coated Drug Delivery Systems with Meloxicam
The objectives of this study are the development and evaluation of modified release multi-particulate drug delivery systems containing a BCS class II drug (meloxicam), formulated as polymer-coated pellets. Inert seeds containing microcrystalline cellulose, lactose monohydrate, and…
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Drug-Loaded Lipid-Core Micelles in Mucoadhesive Films as a Novel Dosage Form for Buccal…
The aim of the study was to develop a novel buccal dosage form to transport rhodamine 123 and human insulin as models for poorly water-soluble and biological drugs, using lipid-core micelles (LCMs)-loaded mucoadhesive films. LCMs were synthesized by a low-energy hot emulsification process, yielding…
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Evaluation on Biorelevant Dissolution Behavior of Propranolol HCl Encapsulated in Various Capsules
Two-piece hard capsules continuously serve as widely used oral drug and dietary supplement dosage forms. Hard gelatin capsules are used in 20% of all oral dosage forms but have numerous shortcomings especially with potential crosslinking with the active ingredient, the growing consumer preference…
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Controlled Delivery of Bile Acids to the Colon
Bile acids, such as chenodeoxycholic acid, play an important role in digestion but are also involved in intestinal motility, fluid homeostasis, and humoral activity. Colonic delivery of sodium chenodeoxycholate (CDC) has demonstrated clinical efficacy in treating irritable bowel syndrome with…
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Rheological characterization of polymeric solutions used in spray drying process
The present works contributes with a rheological characterization of the most commonly used polymers and solvents to formulate amorphous solid dispersions by means of spray drying process: copovidone, hydroxypropyl methylcellulose (HPMC), hydroxypropyl methylcellulose acetate succinate (HPMCAS) and…
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Directly compressible hydroxypropyl methylcellulose (HPMC) to support continuous manufacturing
This work was undertaken to evaluate a novel hydroxypropyl methylcellulose excipient used in the manufacture of hydrophilic matrix tablets for oral controlled release. This material was coprocessed with a small amount of silicon dioxide to provide improvements over the standard material and was…
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Development of a nanoparticle delivery system based on zein/polysaccharide complexes
Zein, an alcohol‐soluble protein in corn, can self‐assemble into spherical nanoparticles, which makes it an ideal carrier material for the encapsulation of hydrophobic bioactive molecules. However, zein nanoparticles easily aggregate in water and are sensitive to enzymatic degradation in the…
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The role of excipient molecular weight in drug release by fibrous dosage forms with close packing…
In this work, drug release by highly drug-loaded, densely-packed fibrous dosage forms is investigated. The formulations consisted of 87wt% ibuprofen drug and 13wt% hydroxypropyl methyl cellulose (HPMC) excipient of molecular weights 10, 26, or 86 kg/mol. The dosage forms were prepared by…
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Towards functional characterization of excipients for oral solid dosage forms using UV-Vis imaging.…
The purpose of this study was to investigate whole-dosage form UV-Vis imaging as a potential tool for functional characterization of excipients used in solid oral dosage forms. To this end, tablets (average mass 260.0 mg, 224.5 mg and 222.1 mg) containing theophylline anhydrate (20% w/w), 1% (w/w)…
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