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HPMC – Hydroxypropylmethylcellulose
Comparative Study of the Mucoadhesive Properties of Polymers for Pharmaceutical Use
In recent years, mucoadhesive dosage forms due to their advantages have attracted the interest of researchers and developers. Polymeric excipients are included into the drug composition to give adhesion to the mucous membrane.
AIM: The aim of this research was to select a specific brand of…
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Polymeric Inserts Containing Eudragit® L100 Nanoparticle for Improved Ocular Delivery of…
Polymeric inserts containing azithromycin-loaded Eudragit® L100 nanoparticles were developed to sustain the drug release and enhance its ocular performance. The solvent diffusion technique was employed to prepare nanoparticles. The developed nanoparticles (NPs) were fully characterized and…
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Meggle Reta M® – The Interview
MEGGLE released the new excipient Reta M® at October 13. Pharma Excipients used the chance to do an interview with the responsible product manager, Dr. Christian Nowak, to learn more about Reta M®. It is the first hypromellose/mannitol-based, co-processed excipient specifically designed for direct…
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Development of Sustained Release Lipid-Based Matrix Microparticles for Vaginal Delivery using…
The development of sustained-release formulations for drugs administered via the vaginal route has the potential to increase treatment efficiency and patient compliance. One promising strategy to formulate such dosage forms is the incorporation of microparticles into a bio-adhesive gel. The main aim…
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Anti-obesity effect with reduced adverse effect of the co-administration of mini-tablets containing…
The purpose of this study was to develop an oral dosage form of orlistat for the treatment of obesity with reduced adverse effects, for example, fatty and oily stool that have been reported to be associated with the mechanism of action of orlistat. Based on the in vitro results obtained in this…
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Starch-based controlled release matrix tablets: Impact of the type of starch
Different types of starches were used to prepare controlled release tablets loaded with diprophylline by direct compression. The impact of the natural origin of the starch, potential chemical modifications (e.g., cross-linking with phosphate or adipate, hydroxypropylation, acetylation to different…
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A Biopredictive In Vitro Approach for Assessing Compatibility of a Novel Pediatric Hydrocortisone…
The objective of the present work was to screen whether a novel pediatric hydrocortisone granule formulation can be co-administered with common food matrices and liquids.
Methods
Pediatric hydrocortisone granules were studied using a biopredictive in vitro approach. Experiments included an in…
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3D printing of solid oral dosage forms: numerous challenges with unique opportunities
Since the FDA approval of Spritam, there has been a growing interest in the application of 3D printing in pharmaceutical science. 3D printing is a method of manufacturing involving the layer-by-layer deposition of materials to create a final product according to a digital model. There are various…
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Interaction between mucoadhesive cellulose derivatives and Pluronic F127: investigation on the…
Systems composed of bioadhesive and thermoresponsive polymers can combine in situ gelation with bio/mucoadhesion, enhancing retention of topically applied drugs. The effect of bioadhesive sodium carboxymethylcellulose (NaCMC) and hydroxypropyl methylcellulose cellulose (HPMC) on the properties of…
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Overcoming the Solubility Barrier of Ibuprofen by the Rational Process Design of a Nanocrystal…
Wet media milling, coupled with spay drying, is a commonly proposed formulation strategy for the production and solidification of nanosuspensions in order to overcome the solubility barrier of BCS Class II substances. However, the application of mechanically and thermally intensive processes is not…
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