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HPMC – Hydroxypropylmethylcellulose
Nanoprecipitation: Applications for Entrapping Active Molecules of Interest in Pharmaceutics
Nanoprecipitation technique, also named solvent injection, spontaneous emulsification, solvent displacement, solvent diffusion, interfacial deposition, mixing-induced nanoprecipitation, or flash nanoprecipitation, is recognized as a useful and versatile strategy for trapping active molecules on the…
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Hot-Melt Extrusion as an Advantageous Technology to Obtain Effervescent Drug Products
Here, we assessed the feasibility of hot-melt extrusion (HME) to obtain effervescent drug products for the first time. For this, a combined mixture design was employed using paracetamol as a model drug. Extrudates were obtained under reduced torque (up to 0.3 Nm) at 100 °C to preserve the stability…
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Continuous twin screw granulation: Robustness of lactose/MCC-based formulations
In recent years, significant progress has been made in the field of continuous twin screw granulation. However, only limited knowledge is currently available on the impact of active pharmaceutical ingredient (API) properties on granule quality and processability. In this study, the response behavior…
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In-situ forming implants for dual controlled release of chlorhexidine and ibuprofen for…
In-situ forming implants (ISFI) which simultaneously release an antimicrobial and anti-inflammatory drug in a controlled manner offer an interesting potential for local periodontitis treatment. In this study, poly(lactic-co-glycolic acid) (PLGA)-based implants loaded with chlorhexidine and ibuprofen…
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Robustness Optimization of an Existing Tablet Coating Process Applying Retrospective Knowledge…
The objective of these studies is to verify and validate the improvement in the inter-tablet coating uniformity for an industrially commercialized coated tablet, without involving changes in the approved registration dossier. Using the CPP (critical process parameters) determined from previous…
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Supercritical Antisolvent Process for Pharmaceutical Applications: A Review
The supercritical antisolvent (SAS) technique has been widely employed in the biomedical field, including drug delivery, to obtain drug particles or polymer-based systems of nanometric or micrometric size. The primary purpose of producing SAS particles is to improve the treatment of dierent…
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Comparison of Different Liquid and Semisolid Vehicles Selected for Oral Administration of Pellets…
The acceptability and palatability of a dosage form are extremely important to improve patient compliance. Mixing oral solid dosage forms with food carriers is often necessary to ease swallowing and provide the taste-masking effect. The present research investigated how a liquid or semisolid carrier…
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In Vitro Evaluation of Enteric-Coated HPMC Capsules – Effect of Formulation Factors on Product…
A comparative study on different enteric-coated hard capsules was performed. The influence of different formulation factors like choice of enteric polymer, triethyl citrate (TEC) concentration (plasticizer), talc concentrations (anti-tacking agent), and different coating process parameters on the…
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Formulation of Sustained Release Hydrophilic Matrix Tablets of Tolcapone with the Application of…
Hydrophilic matrix tablets are a type of sustained release dosage form characterized by distributing a drug in a matrix that is usually polymeric. Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase. In recent years, it has been shown that tolcapone is a potent inhibitor of…
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Optimized flurbiprofen sustained-release matrix pellets prepared by extrusion/spheronization
Flurbiprofen (FBP) is an ibuprofen derivative with less gastric side effects and short biological half-life (4.7–5.7 h). The study aimed to formulate FBP as a sustained-release pellets by extrusion/spheronization to overcome its short half-life and to decrease dose frequency. The wet mass of the…
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