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HPMC – Hydroxypropylmethylcellulose
Biopharmaceutical implications of excipient variability on drug dissolution from immediate release…
Elucidating the impact of excipient variability on oral product performance in a biopharmaceutical perspective would be beneficial and allow excipient implementation on Quality by Design (QbD) approaches. The current study investigated the impact of varying viscosity of binders (hypromellose (HPMC))…
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Jet lag treatment with controlled release melatonin and caffeine
Multi-particulate Dome matrix with sustained-release melatonin and delayed-release caffeine was designed to restore jet lag sleep-wake cycle. The polymeric pellets were produced using extrusion-spheronization technique and fluid-bed coated when applicable. The compact and Dome module were produced…
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Nanoliposomes in polymeric granules: Novel process strategy to produce stable and versatile delivery…
Liposomes, due to their mimetic cellular composition, are gaining great attention as release systems for lipophilic and hydrophilic molecules. However, liposomes can present a high tendency to degrade and aggregate into biological fluids and under storage conditions. To overcome these limitations,…
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In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations
The extensive use of oral dosage forms for the treatment of diseases may be linked to deficient pharmacokinetic properties. In some cases the drug is barely soluble; in others, the rapid transit of the formulation through the gastrointestinal tract (GIT) makes it dicult to achieve therapeutic levels…
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Smart polymers for colon targeted drug delivery systems: a review
The colon targeted drug delivery has a number of important implications in the field of pharmacotherapy. Oral colon targeted drug delivery systems have recently gained importance for delivering a variety of therapeutic agents for both local and systemic administration. Targeting of drugs to the…
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A Comparison of Drug Release and Adsorption Under Supersaturating Conditions for Ordered Mesoporous…
Incomplete drug release from mesoporous silica systems has been observed in several studies. This work aims to increase understanding of this phenomenon by investigating the mechanism of drug-silica interactions and adsorption behaviour from supersaturated aqueous solutions of two similar drug…
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Conversion of indomethacin nanosuspensions into solid dosage forms via fluid bed granulation and…
Preparation of pharmaceutical nanosuspensions is a popular technique to increase the dissolution velocity of poorly water-soluble drugs. Subsequent drying into a compaction-ready powder or granule is a critical process due to possible adverse solid characteristics and the risk of growth of…
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Enteric-coated HPMC capsules: Comparison of enteric coatings and investigation of relationship…
Polymeric film coating of oral solid dosage forms may generate products that exhibit controlled release of active ingredients, physical and chemical protection of the ingredients from the external environment as well as taste masking properties. Among controlled release products, sustained and…
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Regulating the pH of bicarbonate solutions without purging gases: Application to dissolution testing…
Dissolution media based on bicarbonate buffers closely mimic the environment of intestinal fluids and thus improve in vitro in vivo correlation compared to phosphate buffers. Purging gases into the medium is used as a method to stabilise bicarbonate buffers; however, this causes issues due to the…
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Development and characterisation of novel poly (vinyl alcohol)/poly (vinyl pyrrolidone)-based…
Highlights
Novel hydrogel-forming microneedles were produced.
Their physicochemical properties were promising.
Methotrexate was successfully delivered in vitro and in vivo.
Methotrexate (MTX) is one of the mainstays of treatment for rheumatoid arthritis (RA) and juvenile idiopathic…
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