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HPMC – Hydroxypropylmethylcellulose
Novel Cleaning-in-Place Strategies for Pharmaceutical Hot Melt Extrusion
To avoid any type of cross-contamination, residue-free production equipment is of utmost importance in the pharmaceutical industry. The equipment cleaning for continuous processes such as hot melt extrusion (HME), which has recently gained popularity in pharmaceutical applications, necessitates…
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Tylopur® DG-4T – Special polymer for the preparation of hand sanitizer gel
A special Hypromellose type
Hand sanitizer gel is a hydroalcoholic gel formulated with a high level of alcohol. The Center for disease control and prevention (CDC) recommends a minimum of 60 percent alcohol for an alcohol-based hand sanitizer.
Hypromellose (HPMC)…
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Mucoadhesive bilayered buccal platform for antifungal drug delivery into the oral cavity
A drug delivery technology comprising a mucoadhesive bilayered buccally anchored tablet containing natamycin was developed. The concept was to anchor the tablet to the buccal tissue and allow controlled release of the drug through the matrix into the mouth. Carbomer (Carbopol ® 974 P NF) was used to…
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Impact of excipient choice on the aerodynamic performance of inhalable spray-freeze-dried powders
Spray-freeze-drying (SFD) is a process in which a solution is dispersed into a freezing medium and dried by sublimation, resulting in lyophilized powders with spherical particles. This study aims at screening and evaluating the impact of the excipient choice and spray solution characteristics in SFD…
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Mechanodegradation of polymers: a limiting factor of mechanochemical activation in the production of…
In this study we report on the influence of mechanochemical activation on the chemical stability of amorphous solid dispersions made up of indomethacin and HPMC, PVP, PVPVA or Soluplus®. In agreement with our recently published work, all applied carriers were found to be prone to chemical…
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Oral Fixed-Dose Combination Pharmaceutical Products: Industrial Manufacturing Versus Personalized 3D…
Fixed-dose combination (FDC) products containing at least two different active pharmaceutical ingredients are designed to treat more effectively different pathologies as they have demonstrated to enhance patient compliance. However, the combination of multiple drugs within the same dosage form can…
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Solving the Insoluble with AFFINISOL™ HPMC
AFFINISOL™ hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement by maintaining stable solid dispersions and inhibiting API crystallization.
More sophisticated drug discovery techniques have led to pipeline compounds that require…
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QbD aided development of ibrutinib-loaded nanostructured lipid carriers aimed for lymphatic…
Ibrutinib (IBR) is the choice of drug for the treatment of chronic lymphocytic leukaemia (CLL) and mantle cell lymphoma (MCL). IBR has low oral bioavailability of 2.9% owing to its high first pass metabolism. Present study was aimed to develop the nanostructured lipid carriers (NLC) using glyceryl…
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Formulation and evaluation of luteolin supersaturatable self-nanoemulsifying drug
The current investigation was aimed to enhance the solubility and oral bioavailability of luteolin by employing the supersaturable self-nanoemulsifying drug delivery system(S-SNEDDS). The formulation for SNEDDS consisted of caprylic/capric triglyceride, polyoxyl 35 hydrogenated castor oil and…
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Transformation of essential minerals into tablet formulation with enhanced stability
Essential minerals play a very important role in maintaining our physical well-being. In this work, essential minerals; copper sulphate, zinc sulphate, selenium dioxide, chromium picolinate, sodium molybdate and potassium iodide were prepared into tablet formulation with enhanced stability. These…
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