Browsing Category
HPMC – Hydroxypropylmethylcellulose
Hypromellose – A traditional pharmaceutical excipient with modern applications in oral and…
Hydroxypropylmethylcellulose (HPMC), also known as Hypromellose, is a traditional pharmaceutical excipient widely exploited in oral sustained drug release matrix systems. The choice of numerous viscosity grades and molecular weights available from different manufacturers provides a great variability…
Read More...
Read More...
Effect of common excipients on intestinal drug absorption in Wistar rats
The aim of the present paper is to study the effect of common excipients on the permeability of atenolol (as drug absorbed mainly by passive diffusion) and rhodamine (as P-Glycoprotein substrate). Apparent permeability was measured by in situ perfusion method in Wistar rats using the Closed loop…
Read More...
Read More...
Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution…
The intrinsic dissolution rate (IDR) of active pharmaceutical ingredients (API) is a key property that aids in early drug development, especially selecting formulation strategies to improve dissolution and thereby drug absorption in the intestine.
Here, we developed a robust method for rapid,…
Read More...
Read More...
Temperature: an overlooked factor in tablet disintegration
Disintegration is the first event in the bioavailability cascade after the ingestion of immediate release tablets. Although the influence of various physico-chemical parameters of media on tablet disintegration has been investigated in depth, the role of temperature has received much less attention.…
Read More...
Read More...
Influence of binder attributes on binder effectiveness in a continuous twin screw wet granulation…
The effect of a wide variety of binders on the quality of granules produced via continuous twin screw wet granulation was studied. Anhydrous dicalcium phosphate was used as poorly soluble filler and was granulated applying dry or wet addition of binders. Furthermore, dry and wet binder…
Read More...
Read More...
Erodible Coatings Based on HPMC and Cellulase for Oral Time-Controlled Release of Drugs
Oral drug delivery systems for time-controlled release, intended for chronotherapy or colon targeting, are often in the form of coated dosage forms provided with swellable/soluble hydrophilic polymer coatings. The latter are responsible for programmable lag phases prior to release, due to their…
Read More...
Read More...
In-line temperature measurement to improve the understanding of the wetting phase in twin-screw wet…
Wetting is the initial stage of wet granulation processes during which the first contact between the powder and the liquid occurs. Wetting is a critical step to allow granule growth and consolidation, but also to ensure uniform active pharmaceutical ingredient (API) distribution over all granule…
Read More...
Read More...
Sustained release – made from nature with Tylopur Xtend Nutra®
XTENDED RELEASE OF ACTIVE INGREDIENTS FOR NUTRACEUTICAL & NUTRITIONAL APPLICATIONS
Tylopur Xtend Nutra® is a plant derived cellulose-based ingredient produced by Shin-Etsu. It is specifically developed for nutraceutical and nutritional applications. It enables xtended release of…
Read More...
Read More...
Electrospun Orodispersible Films of Isoniazid for Pediatric Tuberculosis Treatment
Child-appropriate dosage forms are critical in promoting adherence and effective pharmacotherapy in pediatric patients, especially those undergoing long-term treatment in low-resource settings. The present study aimed to develop orodispersible films (ODFs) for isoniazid administration to children…
Read More...
Read More...
Moisture sorption and desorption properties of gelatin, HPMC and pullulan hard capsules
The moisture sorption and desorption properties of hard capsules have a great influence on the quality of capsule products. However, studies on them have rarely been reported. Herein, we studied the moisture sorption and desorption properties of three kinds of hard capsules (gelatin, hydroxypropyl…
Read More...
Read More...