HPMC – Hydroxypropylmethylcellulose

The aim of this study was to develop direct compressed and lyophilized fast disintegrating/dissolving tablets (FDTs) that enhanced disintegration and dissolution of deferasirox, a drug with poor solubility and bioavailability. Although there are conventional oral tablets and tablets for oral…
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Controlled release tablets are important dosage forms enabling a slower release of the drug and better pharmacokinetics for some drugs and hydrophilic matrix tablets utilizing hydroxypropyl methylcellulose (HPMC) are one of the most common types. One of the main challenges with using HPMC is its…
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The multiple-unit sustained-release (MUSR) dosage forms containing numerous sustained-release subunits present a reliable choice for oral formulation of controlled release systems. As a typical MUSR, the metoprolol succinate sustained-release tablet is an advanced system with limited researches…
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Abiraterone is a poorly water-soluble drug. It has a high melting point and limited solubility in organic solvents, making it difficult to formulate as an amorphous solid dispersion (ASD) with conventional technologies. KinetiSol® is a high-energy, fusion-based, solvent-free technology that can…
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The co-processing of multiple excipients is driven by the potential of diversifying the properties and functionality of excipients when they are combined. Bulk freeze-drying-milling is a novel secondary processing approach to develop co-processed excipients. It offers a significant advantage of…
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Multiple carriers may be used to prepare solid dispersions (SDs) for different purposes. The aim of this work is to investigate the effect of the third component on the physical stability and physical aging behavior of cinnarizine-soluplus SDs. HPMC, PVP, sorbitol and citric acid were used as the…
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Zein is an insoluble, yet swellable, biopolymer that has been extensively studied for its applications in drug delivery. Here, we screened the effect of co-excipients on the swelling and drug release of zein tablets. All throughout the study the behavior of zein was benchmarked against that of…
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Hydroxypropyl methylcellulose (HPMC) is a frequently used matrix former for controlled release tablets. To adjust desired drug release kinetics, freely water-soluble lactose can be added. The aim of this study was to investigate the importance of the type of preparation technique of propranolol…
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If you need technical information and practical tips to formulate with your lipid excipients, Gattefossé has prepared different case studies for download after registration. How to obtain sustained release tablets of metformin hydrochloride by direct compression? The aim was to develop dual SR…
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Nanotechnology is now considered a promising drug delivery method for orally administered hydrophobic drugs to their sites of action. The effect of nanodispersion on cellular transport and accumulation of saquinavir (SQV) was investigated. Methods The transport of five solid drug…
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