Browsing Category
HPMC – Hydroxypropylmethylcellulose
Application of 3D printing in early phase development of pharmaceutical solid dosage forms
Abstract
Three-dimensional printing (3DP) is an emerging technology, offering the possibility for the development of dose-customized, effective, and safe solid oral dosage forms (SODFs). Although 3DP has great potential, it does come with certain limitations, and the traditional drug manufacturing…
Read More...
Read More...
Sample Size Requirements of a Pharmaceutical Material Library: A Case in Predicting Direct…
The material library is an emerging, new data-driven approach for developing pharmaceutical process models. How many materials or samples should be involved in a particular application scenario is unclear, and the impact of sample size on process modeling is worth discussing. In this work, the…
Read More...
Read More...
Development of multiple structured extended release tablets via hot melt extrusion and dual-nozzle…
Abstract
The study aims to fabricate extended release (ER) tablets using a dual-nozzle fused deposition modeling (FDM) three-dimensional (3D) printing technology based on hot melt extrusion (HME), using caffeine as the model compound. Three different ER tablets were developed, which obtained…
Read More...
Read More...
Biopolymer Packaging Materials in the Pharmaceutical Industry
Biopolymer packaging materials are gaining prominence in the pharmaceutical industry due to environmental concerns. Derived from renewable sources, these biopolymers offer biodegradability, biocompatibility, and non-toxicity, making them ideal for various pharmaceutical applications. In drug…
Read More...
Read More...
Advancing oral drug delivery: The science of fast dissolving tablets (FDTs)
The field of oral drug delivery has witnessed significant advancements, with a focus on developing innovative formulations to address challenges associated with traditional dosage forms, especially for patients with difficulties in swallowing. Fast Dissolving Tablets (FDTs) have emerged as a…
Read More...
Read More...
Tableting of coated multiparticulates: Influences of punch face configurations
Abstract
The influences of the punch face design on multi-unit pellet system (MUPS) tablets were investigated. Drug-loaded pellets coated with sustained release polymer based on ethylcellulose or acrylic were compacted into MUPS tablets. Punch face designs used include standard concave, deep…
Read More...
Read More...
A Comprehensive Review of Disintegrants: Backbone of disintegration
Abstract
Strong attractive bonding forces works among the particles of solid dosage forms such as mechanical, solid and intermolecular and bioavailability of solid dosage form is preferentially dependent on in vivo disintegration then dissolution. This review is focused for disintegrating agents,…
Read More...
Read More...
Formulation and Preparation of Losartan-Potassium-Loaded Controlled-Release Matrices Using Ethocel…
In the current study, matrices of losartan potassium were formulated with two different polymers (Ethocel 10 premium and Ethocel 10FP premium), along with a filler and a lubricant, at different drug-to-polymer w/w ratios (10:3, 10:4, and 10:5). The matrices were tested by the direct compression…
Read More...
Read More...
In Vitro and Biological Evaluation of Oral Fast-Disintegrating Films Containing Ranitidine HCl and…
Flurbiprofen (FBP), a nonsteroidal anti-inflammatory drug (NSAID), is commonly used to treat the pain of rheumatoid arthritis, but in prolonged use it causes gastric irritation and ulcer. To avoid these adverse events of NSAIDs, the simultaneous administration of H2 receptor antagonists such as…
Read More...
Read More...
Changes in Tablet Color Due to Light Irradiation: Photodegradation of the Coating Polymer,…
The color of the tablets and capsules produced by pharmaceutical companies is important from the perspectives of product branding and counterfeiting. According to some studies, light can change tablet color during storage. In this study, tablets comprising amlodipine besylate (AB), a well-known…
Read More...
Read More...