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HPMC – Hydroxypropylmethylcellulose
Formulation and evaluation of dabigatran loaded microballoons for prolonged drug release
The objective of the present investigation was to formulate microballoons loaded with dabigatran in the polymeric core for achieving sustained release and hence improved bioavailability. Microballoons loaded with dabigatran in the polymer shell were prepared by simple solvent evaporation method…
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Liquid API Feeding in Pharmaceutical HME: Novel Options in Solid Dosage Manufacturing
Hot melt extrusion (HME) is a common unit operation. It is broadly applicable in the pharmaceutical industry and can be implemented in a continuous manufacturing line. However, the conventional way of active pharmaceutical ingredient (API) feeding with a pre-blend consisting of a powdered API and a…
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Loss-on-Drying Prediction for a Vibrated Fluidised Bed Dryer by Means of Mass and Energy Balances
Abstract
Purpose
Continuous wet granulation and drying require an adequate process control strategy to ensure the product quality. The most important critical quality attributes of dried granules are the granule size distribution and moisture content. Process analytical technologies (PATs) are…
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pH-dependent pressure-sensitive colonic capsules for the delivery of aqueous bacterial suspensions
Microbiome-based therapies hold great promise for treating various diseases, but the efficient delivery of live bacteria to the colon remains a challenge. Furthermore, current oral formulations, such as lyophilized bacterial capsules or tablets, are produced using processes that can decrease…
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Characterizing a design space for a twin-screw wet granulation process: A case study of…
Abstract
Twin-screw wet granulation is an emerging continuous manufacturing technology for solid oral dosage forms. This technology has been successfully employed for the commercial manufacture of immediate-released tablets. However, the higher polymer content in extended-release (ER) formulations…
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Comparative Dissolution of Budesonide from Four Commercially Available Products for Oral…
ABSTRACT
Budesonide is a corticosteroid regularly used in oral formulations to treat various inflammatory diseases in the
gastrointestinal tract, such as Crohn’s disease and ulcerative colitis. Budesonide has also been formulated to be effective against immunoglobulin A (IgA)-related nephropathy.…
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Preparation of Hot-Melt-Extruded Solid Dispersion Based on Pre-Formulation Strategies and Its…
In this study, an amorphous solid dispersion containing the poorly water-soluble drug, bisacodyl, was prepared by hot-melt extrusion to enhance its therapeutic efficacy. First, the miscibility and interaction between the drug and polymer were investigated as pre-formulation strategies using various…
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Enhancing the solubility and dissolution rate of piperine via preparation of piperine–hydroxypropyl…
Abstract
Context:
Piperine is the main secondary metabolite isolated from the family Piperaceae. This biologically active ingredient has many pharmacological effects, though its low water solubility limits its absorption in gastrointestinal fluid.
Aims:
To improve piperine’s solubility and…
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Recent advances in biopolymer-based mucoadhesive drug delivery systems for oral application
Oral drug delivery is a common and convenient route for administering pharmaceuticals, but it presents challenges related to drug stability, absorption, and targeted delivery. Because of their potential to address these challenges, biopolymer-based mucoadhesive drug delivery systems have received a…
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Retrospective analysis of the biopharmaceutics characteristics of solid oral Modified-Release drug…
Abstract
Background
Modified Release (MR) orally administered drugs products differ from Immediate-Release (IR) drug products in their drug release site and/or rate to offer therapeutic advantages. It is important to understand the biopharmaceutics factors that determine how a drug works in the…
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