Pharma Excipients
Organic Chemicals
Actual Sugars
Artificial Sweeteners
Carbohydrates
Cellulose
Cellulose Esters
Cellulose Ethers
CMC and Croscarmellose Sodium
Converted Starch
Dried Starch
Ethyl Cellulose
HPC - hydroxypropyl cellulose
HPMC - Hydroxypropylmethylcellulose
Microcrystalline Cellulose
Modified Starch
Starch
Sugar Alcohols
Sugars
Trehalose
Addiction to Psychoactive Prescription Drugs: Can the Excipients of the Formulations Play a Role?
Abstract
In the development of drugs misuse and addiction, references are often made to the study of the API (active principle ingredient) as the main cause, which is certainly true, but there is a tendency to overlook the possible role of certain excipients which may be involved in the…
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Development of α-Cyclodextrin-Based Orally Disintegrating Tablets for 4-Phenylbutyrate
Despite major improvements brought about by the introduction of taste-masked formulations of 4-phenylbutyrate (PB), poor compliance remains a significant drawback to treatment for some pediatric and dysphagic patients with urea cycle disorders (UCDs). This study reports on the development of a…
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Hydroxyapatite and pore former effects on the microstructure and mechanical strength of porous…
Porous hydroxyapatite (HAP) pellets were prepared by extrusion/spheronization/sintering and loaded with Lactobacillus (La-5). Micronized (PFm) or coarse size (PFc) microcrystalline cellulose were the pore formers, while HAP grades from Budenheim (Tri-cafos®) and Sigma-Aldrich with different specific…
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Potentially Harmful Excipients: State of the Art for Oral Liquid Forms Used in Neonatology and…
Abstract
The pediatric population exhibits an important age-dependent heterogeneity in pharmacokinetics and pharmacodynamics parameters, resulting in differences in drug efficacy and toxicity compared to the adult population, particularly for neonates. Toxicity and efficacy divergences have been…
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Design, development and scale up studies of metformin hydrochloride multiparticulate system: A…
Metformin hydrochloride (MH) is prescribed for treating diabetes mellitus. The most popular dosage form, viz., tablets has a bulky nature as MH dose ranges up to 1000 mg leading to large size. In geriatric or dysphagic patients, due to altered physiology, swallowing such bulky formulation is…
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Study of Compaction Tools and Parameters on Critical Quality Attributes of High Drug Load…
Minitablets are prepared using multiple die openings and multi–tip punches for greater productivity. With multiple tips on the punch barrel, the overall compaction force to be applied is commonly estimated by multiplying the desired compaction force per tip by the number of punch tips. Few…
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Extended release of flurbiprofen from tromethamine-buffered HPMC hydrophilic matrix tablets
The continued popularity into the 21st century of extended release matrices based on hydroxypropyl methylcellulose (HPMC) can be attributed to (i) the effectiveness of hydrophilic matrix technology, (ii) the high acceptability of the polymer, (iii) the ease of dosage form manufacture and (iv) a…
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The interplay between trehalose and dextran as spray drying precursors for cationic liposomes
Successful oral delivery of liposomes requires formulations designed to withstand harsh gastrointestinal conditions, e.g., by converting to solid-state followed by loading into gastro-resistant delivery devices. The hypothesis was that the use of dextran-trehalose mixtures for spray drying would…
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Febuxostat ternary inclusion complex using SBE7-βCD in presence of a water-soluble polymer:…
Febuxostat (FBX), a potent xanthine oxidase inhibitor, is widely used as a blood uric acid-reducing agent and has recently shown a promising repurposing outcome as an anti-cancer. FBX is known for its poor water solubility, which is the main cause of its weak oral bioavailability. In a previous…
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Development of Subdermal Implants Using Direct Powder Extrusion 3D Printing and Hot-Melt Extrusion…
Implants are drug delivery platforms that consist of a drug-polymer matrix with the ability of providing a localized and efficient controlled release of the drug with minimal side effects and achievement of the desired therapeutic outcomes with low drug loadings. Direct powder extrusion (DPE) 3D…
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