Pharma Excipients
Organic Chemicals
Actual Sugars
Artificial Sweeteners
Carbohydrates
Cellulose
Cellulose Esters
Cellulose Ethers
CMC and Croscarmellose Sodium
Converted Starch
Dried Starch
Ethyl Cellulose
HPC - hydroxypropyl cellulose
HPMC - Hydroxypropylmethylcellulose
Microcrystalline Cellulose
Modified Starch
Starch
Sugar Alcohols
Sugars
Trehalose
Facilitating direct compaction tableting of fine cohesive APIs using dry coated fine excipients:…
The possibility of attaining direct compression (DC) tableting using silica coated fine particle sized excipients was examined for high drug loaded (DL) binary blends of APIs. Three APIs, very-cohesive micronized acetaminophen (mAPAP, 7 μm), cohesive acetaminophen (cAPAP, 23 μm), and easy-flowing …
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Prediction of in-vitro dissolution and tablet hardness from optical porosity measurements
Abstract
Advanced manufacturing technologies such as continuous processing require fast information on the quality of intermediates and products. Process analytical technologies (PAT) to monitor many critical quality attributes (CQAs) have been developed and successfully implemented in…
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3D Screen Printing Offers Unprecedented Anticounterfeiting Strategies for Oral Solid Dosage Forms…
Abstract
A threat to human health in developed and, in particular, in developing countries, counterfeit medicines represent the largest identified fraud market worldwide. 3D screen printing (3DSP), an additive manufacturing technology that enables large-scale production, offers unique opportunities…
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Multi-component mixing and demixing model for predictive finite element modelling of pharmaceutical…
A set of numerical methods is described that allows predictive finite element method (FEM) simulations of the compaction of multi-component pharmaceutical powder formulations across the entire range of compositions. An automated parametrisation procedure was used to extract density-dependent…
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Quality by design approach for fabrication of extended-release buccal films for xerostomia employing…
The study endeavors the fabrication of extended-release adipic acid (APA) buccal films employing a quality by design (QbD) approach. The films intended for the treatment of xerostomia were developed utilizing hot-melt extrusion technology. The patient-centered quality target product profile was…
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Transformation of ABT-199 Nanocrystal Suspensions into a Redispersible Drug Product – Impact…
The present study compared vacuum drum drying (VDD) and conventional spray drying (SD) for solidifying crystalline ABT-199 nanosuspensions into redispersible oral drug products. The aim was to optimize formulation compositions and process conditions to maintain nanoparticle size after tablet…
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Enhanced Bioavailability of Valsartan through Mucoadhesive Pellets Fabricated via Fluidized Bed…
ABSTRACT
Background
Novel delivery strategies are being explored since low bioavailability presents a challenge for medications like valsartan. Mucoadhesive drug delivery systems present a viable alternative by enhancing drug absorption and retention.
Aim
This study aimed to develop…
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Lessons to learn for 3D printing of drug products by semisolid extrusion (SSE)
Abstract
Semisolid extrusion (SSE) 3DP technology is emerging due to its simplicity and potential for on-site manufacturing of personalized drug products with tailored functionality (dose, release profile), as well as recognizability (size, shape, color). However, even a minor change in the…
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In vitro and in vivo studies of ocular topically administered NLC for the treatment of uveal…
Uveal melanoma is one of the most common and aggressive intraocular malignancies, and, due to its great capability of metastasize, it constitutes the most incident intraocular tumor in adults. However, to date there is no effective treatment since achieving the inner ocular tissues still constitutes…
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How oregano essential oil can be transformed into a taste-masking controlled release solid…
Oregano essential oil (OEO) has antioxidant, antiproliferative, anti-inflammatory and antimicrobial activities. OEO could be administered orally for some gastrointestinal diseases, however, its oral use, is severely hampered by its irritant taste, which requires a high dilution in water before…
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