Pharma Excipients
Organic Chemicals
Actual Sugars
Artificial Sweeteners
Carbohydrates
Cellulose
Cellulose Esters
Cellulose Ethers
CMC and Croscarmellose Sodium
Converted Starch
Dried Starch
Ethyl Cellulose
HPC - hydroxypropyl cellulose
HPMC - Hydroxypropylmethylcellulose
Microcrystalline Cellulose
Modified Starch
Starch
Sugar Alcohols
Sugars
Trehalose
Retrospective analysis of the biopharmaceutics characteristics of solid oral Modified-Release drug…
Abstract
Background
Modified Release (MR) orally administered drugs products differ from Immediate-Release (IR) drug products in their drug release site and/or rate to offer therapeutic advantages. It is important to understand the biopharmaceutics factors that determine how a drug works in the…
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Aerogels as Carriers for Oral Administration of Drugs: An Approach towards Colonic Delivery
Polysaccharide aerogels have emerged as a highly promising technology in the field of oral drug delivery. These nanoporous, ultralight materials, derived from natural polysaccharides such as cellulose, starch, or chitin, have significant potential in colonic drug delivery due to their unique…
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Elucidating the Impact of Material Properties on Tablet Manufacturability for Binary Paracetamol…
Abstract
Purpose
Although the mechanical properties of paracetamol and MCC are extensively described in literature, there still is a need for a better understanding of the material properties impacting them. Thus, this study systematically analyzed material properties of paracetamol-MCC blends…
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Evidence of Reliable Gastro-Resistance of Novel Enteric Ready-to-Fill Capsules Simplifying…
Developing delayed-release formulations for acid-sensitive actives can be a costly and time-consuming process. However, ready-to-fill functional capsules, such as EUDRACAP® can significantly mitigate these challenges. The in vitro performance of EUDRACAP® enteric was evaluated in two typical…
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Exploring Environmental Settings to Improve the Printability of Paroxetine-Loaded Filaments by Fused…
The successful integration of hot-melt extrusion (HME) and fused deposition modelling (FDM) depends on a better understanding of the impact of environmental conditions on the printability of formulations, since they significantly affect the properties of the raw materials, whose control is crucial…
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Development of a PAT platform for the prediction of granule tableting properties
In this work, the feasibility of implementing a process analytical technology (PAT) platform consisting of Near Infrared Spectroscopy (NIR) and particle size distribution (PSD) analysis was evaluated for the prediction of granule downstream processability. A Design of Experiments-based calibration…
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VITAMIN E – Direct Compression with PROSOLV 730
Aim of the study
Solid dose formulations of Vitamin E, an oily active ingredient, are typically produced as soft-gel capsules in the pharmaceutical and nutraceutical industry. The manufacturing process of these soft-gel capsules is labor-intensive and costly. The goal of this study was to create…
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Advances in antimicrobial polymeric iodophors
Abstract
Despite centuries of research on this chemical element, the ability of iodine to form complexes with water-soluble polymers and various other molecules remains a topic of great interest. The fascination with iodine and iodophors arises from their remarkable antimicrobial properties against…
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Investigations on Compaction Behavior of Kollidon®SR-Based Multi-component Directly Compressed…
The physics of tablets mixtures has gained much attention lately. The purpose of this work is to evaluate the compaction properties of Kollidon® SR (KSR) in the presence of different excipients such as Microcrystalline cellulose (MCC), Monohydrous lactose (MH Lactose), Poly (vinyl acetate) (PVA100),…
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Tableting properties of freeze-dried trehalose: physico-chemical and mechanical investigation
Abstract
Freeze-drying of biopharmaceutical products is the method of choice in order to improve their stability and storage conditions. Such Freeze-dried products are usually intended for parenteral route administration. However, many biopharmaceutical materials administered by parenteral route…
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