Pharma Excipients
Starch
Fabrication and Characterization of Orodispersible Composite Film from Hydroxypropylmethyl…
Crosslinked carboxymethyl rice starch (CLCMRS), prepared via dual modifications of native rice starch (NRS) with chloroacetic acid and sodium trimetaphosphate, was employed to facilitate the disintegration of hydroxypropylmethylcellulose (HPMC) orodispersible films (ODFs), with or without the…
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Controlled release starch-lipid implant for the therapy of severe malaria
Parenteral depot systems can provide a constant release of drugs over a few days to months. Poly-(lactic acid) (PLA) and Poly-(lactide-co-glycolide) (PLGA) are the most commonly used polymers in the production of these systems. Finding alternatives to these polymers is of great importance to avoid…
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Oral Thin-films from Design to Delivery: A Pharmaceutical Viewpoint
Stable drug-type tablets and capsules are painful to drink or chew for many pediatric and geriatric patients. Accurate dosing is also an issue for liquid orals (syrup, suspension, emulsion, and so on). Several fast-dissolving drug delivery systems have been designed to address these issues. One of…
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Recent Advancements in Microneedle Technology for Multifaceted Biomedical Applications
Microneedle (MNs) technology is a recent advancement in biomedical science across the globe. The current limitations of drug delivery, like poor absorption, low bioavailability, inadequate skin permeation, and poor biodistribution, can be overcome by MN-based drug delivery. Nanotechnology made…
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Sodium Starch Glycolate as a Superdisintegrant – Review Article
Sodium starch glycolate (SSG) is most widely used excipient in the field of pharmaceutical sciences. SSG is extensively used as a superdisintegrant in different drug formulations. This review article aims to discuss chemistry, synthesis, level used as superdisintegrant, different types of SSG’s and…
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Hydration and dehydration induced changes in porosity of starch microspheres
Characterization and tuning of the porosity of amorphous starch materials are important for many applications, including controlled release of encapsulated proteins. The porosities of these materials in dry and hydrated states can have different physicochemical origins and properties. Here,…
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High-amylose maize starch as a novel film former to develop oral films with excellent mechanical…
Aim: The study involved the development and optimization of the fast-dissolving oral films of salbutamol sulfate using high-amylose maize starch (HAMS) as a novel film former by comparison with the HPMC E50 (hydroxy propyl methyl cellulose) films. The high aqueous solubility, low dose, and low…
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Changes in the Structure, Thermodynamic, and Functional Properties of Maize Starch During Mechanical…
The results of research on the structural, thermodynamic, and physicochemical properties of normal maize starch subjected to mechanical processing in a ball mill for different time intervals are presented. It is shown that in the process of mechanical processing, abrasion and splitting of starch…
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Compression Modulus and Apparent Density of Polymeric Excipients during Compression—Impact on…
The present study focuses on the compaction behavior of polymeric excipients during compression in comparison to nonpolymeric excipients and its consequences on commonly used Heckel analysis. Compression analysis at compaction pressures (CPs) from 50 to 500 MPa was performed using a compaction…
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Semi-solid extrusion 3D printing of starch-based soft dosage forms for the treatment of paediatric…
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could share their work in addition online with the Pharma Excipients…
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