Starch

Three-dimensional printed drug development is nowadays an active area in the pharmaceutical industry, where the search for an appropriate edible carrier that permits the thermal processing of the mixture at temperature levels that are safe for the drug is an important field of study. Here, potato…
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Background Computer-aided formulation design is gaining fantastic attention in chemical engineering of high functionality pharmaceutical materials for dosage form manufacture. To accelerate development of novel formulations in a quality-by-design perspective, SeDeM Expert System preformulation…
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Background: Counterfeit medicines are an increasing scourge that are difficult to identify and they have become industrialized and widespread through highly organized illegal channels. Objective: This research aims to develop a robust method to determine four phosphodiesterase type-5 inhibitors…
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Introduction Stable active pharmaceutical ingredients (APIs) represent a critical success factor for drug formulation for four main reasons. Firstly, the potential instability of APIs can represent a critical threat to patient safety. This risk can be generated through the decline in the actual…
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Amphiphilic starches (sodium octenylsuccinate starches) are a well‐known emulsifier for various food and pharma applications. Typical applications are the encapsulation of lipophilic compounds such as vitamins and other micronutrients or the direct or indirect solubilization of drug substances . To…
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Pharmatrans Sanaq has now added DICOM SP 204 tailored to help formulation development of moisture sensitive APIs and to stabilize formulations where alkaline conditions need to be controlled to its DICOM SANAQ® range of high functionality co-processed excipients. SANAQ® SP 204  is a co-processed…
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Comprehensive understanding of an integrated continuous pharmaceutical technology was achieved in this study by a combining design of experiments and mechanistic modeling-based simulations. The powder to granule line consisted of twin-screw wet granulation, vibrational fluid-bed drying and milling.…
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Developing new pharmaceuticals is costly and time-consuming. New methods are always in demand for various stages of product development. Investing in the early phases of development can save a significant amount of resources in the long term. Tablet is still the most commonly used pharmaceutical…
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The suitability of pharmaceutical binders for continuous twin-screw wet granulation was investigated as the pharmaceutical industry is undergoing a switch from batch to continuous manufacturing. Binder selection for twin-screw wet granulation should rely on a scientific approach to enable efficient…
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Pharmaceutical excipient development is an extensive process requiring a series of pre-formulation studies to evaluate their performance. The present study compares the conventional compaction and compression pre-formulation studies with artificial intelligence (AI) modeling to predict the…
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