Pharma Excipients
Starch
Fabrication and evaluation of fast disintegrating pellets of cilostazol
The present study was designed to formulate and develop fast disintegrating pellets of poorly soluble model drug (cilostazol) by reducing the proportion of micro-crystalline cellulose with pre-gelatinized starch (PGS), lactose and chitosan. The bioavailability enhancement of a model drug was…
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Characterization and modeling of the viscoelasticity of pharmaceutical tablets
Evolution of the compaction properties of powders with the compaction speed (strain rate sensitivity, SRS) is a common phenomenon during the manufacturing of pharmaceutical tablets. Nevertheless, several different phenomena can be responsible of the SRS like friction, viscoelasticity,…
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3D printed gummies: Personalized drug dosage in a safe and appealing way
Obtention of customized dosage forms is one of the main attractions of 3D printing in pharmaceuticals. In this sense, children are one of the groups within the population with a greater need for drug doses adapted to their requirements (age, weight, pathological state…), but most 3D printed oral…
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Orodispersible Tablets (ODTs) – Overcoming you main challenges
Orally Disintegrating Tablets (ODTs) are getting increasingly interesting delivery systems in the pharmaceutical and nutraceutical fields. They are an innovative way to handle the product lifecycle management, generate market differentiation, and increase the interest of consumers.
This webinar…
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Tablet Quality-Prediction Model Using Quality Material Attributes: Toward Flexible Switching Between…
Purpose
The purpose of the study was to develop a model to predict the critical quality attribute (CQA) of tablets during continuous and batch manufacturing using only critical material attributes (CMAs).
Methods
Experiments were performed using ethenzamide as the active pharmaceutical…
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Studies to predict the effect of pregelatinization on excipient property of maize and potato starch…
This study focuses on the effect of co-processing on physicochemical and drug release properties of starch mixtures. Different mixtures of native maize and potato starch were pregelatinized for different time intervals. The pregelatinized starch mixture was observed to have higher amylose content…
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Fabrication of Polylactic Acid/Paclitaxel Nano Fibers by Electrospinning for Cancer Therapeutics
Background: Polylactic acid (PLA) is a thermoplastic and biodegradable polyester, largely derived from renewable resources such as corn starch, cassava starch and sugarcane. However, PLA is only soluble in a narrow range of solvents such as tetrahydrofuran, dioxane, chlorinated solvents and heated…
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A Precise Prediction Method for the Properties of API-Containing Tablets Based on Data from Placebo…
We previously reported a novel method for the precise prediction of tablet properties (e.g., tensile strength (TS)) using a small number of experimental data. The key technique of this method is to compensate for the lack of experimental data by using data of placebo tablets collected in a database.…
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Design, Optimization, and Correlation of In Vitro/In Vivo Disintegration of Novel Fast Orally…
Compression of cohesive, poorly compactable, and high-dose metformin hydrochloride into the orally disintegrating tablet (ODT) is challenging. The objective of this study was to develop metformin ODT using the moisture activated dry granulation (MADG) process.
There are no reports in the…
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StarLac® for Orally Disintegrating Tablets
Oral application of drugs is not only the most common way for systemic drug application, it is also patient’s route of choice. Oral formulations are – compared to injections or infusions – convenient and painless. As they do not require sterility they are cost effective and reveal good patient…
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