Pharma Excipients
Starch
Comparative dissolution studies on granules with acetaminophen and caffeine using the basket and…
Acetaminophen and caffeine, popular therapeutic substances used to relieve pain or alleviate the symptoms of cold.
The aims of the study were the comparison of granules, in terms of dissolution rate and moreover the development of spectrophotometric method to the simultaneous determination of…
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Production of Directly Compressible Excipients With Mannitol By Wet Granulation: Rheological,…
The purpose of this research was to produce co-processed excipients using mannitol as base material with some of the most used binders: potato, maize pre-gelatinized starch, and K-25, K-29/32, K-90 povidone.
Mannitol, one commercial based mannitol product, and the produced materials were…
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Investigation of the effect of compaction speed on the compressional behavior of microcrystalline…
The main goal of this thesis was to examine the effect of the compaction speed on the compressional behavior of two excipients, microcrystalline cellulose and starch, using an eccentric and rotary presses.
First, the average weights of the tablets have changed due to the increasing speed, as the…
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A study of anionic, cationic, and nonionic surfactants modified starch nanoparticles for hydrophobic…
Starch nanoparticles were prepared from native potato starch using acid hydrolysis and precipitation methods.
The acid hydrolysis method yielded high relative crystallinity of starch nanoparticles (SNP-H), while ethanol precipitation method resulted in nanoparticles (SNP-P) with low…
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Chemically Modified Starches as Excipients in Pharmaceutical Dosage Forms
Excipients play a great role in ensuring that pharmaceutical dosage form meets the required specifications of quality approved by the relevant authorities.
Starches are the most widely used excipients in dosage form development, but their use is enhanced by several modification methods (such as…
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Native starch as in situ binder for continuous twin screw wet granulation
The use of native starch as in situ binder in a continuous twin screw wet granulation process was studied.
Gelatinization of pea starch occurred in the barrel of the granulator using a poorly soluble excipient (anhydrous dicalcium phosphate), but the degree of gelatinization depended on the…
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Formulation, Development and Scale-Up of Fixed-Dose Combination Tablets Containing Zidovudine,…
The development of antiretroviral associations in a single dosage form aims to ensure good efficacy, low costs and better adherence to treatment.
Thereby, this work aimed to perform the pharmacotechnical development and stability studies of coated tablets of fixed-dose combination of zidovudine,…
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Ampholytic and Polyelectrolytic Starch as Matrices for Controlled Drug Delivery
The potential of the polyampholytic and polyelectrolytic starch compounds as excipients for drug controlled release was investigated using various tracers differing in terms of solubility and permeability.
Ampholytic trimethylaminecarboxymethylstarch (TMACMS) simultaneously carrying…
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Polysaccharide and polypeptide based injectable thermo-sensitive hydrogels for local biomedical…
Injectable thermo-responsive hydrogels have been studied for various biomedical applications including; drug delivery, cell encapsulation, and tissue repairing. There are various natural and synthetic polymers which exhibit homogenous injectable solution at ambient temperature and form a gel in…
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A novel bitter masking approach: Powder coating technology-take Sanhuang tablets as an example
Sanhuang tablets (SHT) had a broad antibiotic spectrum with high efficiency and low toxicity. However, the clinical application was seriously limited by extremely bitter taste.
A novel powder coating technology was established to mask the bitter taste of Sanhuang powder (SHP). Initially, the type…
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