Pharma Excipients
Starch
Application of natural polymers as pharmaceutical excipients
The use of natural polymer as excipients in pharmaceutical sector is expanding day by day. Low cost, safety degradable are the main causes that make them differ from other sources. Natural sources have wide range of varieties and characteristics. So they can be used…
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Efficient Mucosal Immunization by Mucoadhesive and pH-Sensitive Polymeric Vaccine Delivery System
Mucosal surfaces as the largest immune organ of human body cover 400 m2 of the body including the gastrointestinal, urogenital, and respiratory tracts. The local mucosal immunity is an important first line of defense against many pathogens because most pathogens initiate their infection through…
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Effect of Binder Attributes on Granule Growth and Densification
The rate and extent of granule growth and densification during high-shear wet granulation (HSWG) depends on a variety of formulation and process variables, including material attributes of critical formulation excipients, such as binders. The effects of known binder attributes to the rate and extent…
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Influence of Ar plasma treatment on the wetting behavior of pharmaceutical powders
In this study, corn starch and ibuprofen are treated in Argon (Ar) plasma to enhance the wettability of the powders without using any additive or guest particle. The powder and pellets were exposed to the Ar plasma for different time intervals (5–20 min) at optimized pressure and voltage. While the…
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Challenges in Transitioning Cocrystals from Bench to Bedside: Dissociation in Prototype Drug Product…
18. July 2018
Tablets containing a theophylline–glutaric acid (TG) cocrystal dissociated rapidly forming crystalline theophylline (20–30%), following storage at 40 °C/75% RH for 2 weeks. Control tablets of TG cocrystal containing no excipients were stable under the same…
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Self-stabilized chitosan and its complexes with carboxymethyl starch as excipients in drug delivery
13. May 2018
This study focuses on the behavior of chitosan (CHI) and its polyelectrolyte complexes with carboxymethyl starch (CMS) used as monolithic matrices with acetaminophen as drug tracer. Two different chitosan grades were tested alone or associated in various ratios with CMS…
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Flow, compaction and tabletting properties of co-processed excipients using pregelatinized Ofada…
31. March 2018 The growing popularity of direct-compression process necessitates an ideal filler–binder that can substitute two or more excipients. Pregelatinization of starches significantly improves swelling and flow properties…
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Starch film-coated microparticles for oral colon-specific drug delivery
19. March 2018 The aim of this study was to prepare and characterize a novel type of starch-coated microparticles (MPs) allowing site-specific delivery of bioactives to the colon. An oral colon-specific controlled-release system…
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Starch-Chitosan Polyplexes: A Versatile Carrier System for Anti-Infectives and Gene Delivery
08. March 2018 Despite the enormous potential of nanomedicine, the search for materials from renewable resources that balance bio-medical requirements and engineering aspects is still challenging. This study proposes an easy…
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Comparison of co-processed starches prepared by 3 different methods
08. November 2017
Abstract
Co-processing is currently of interest in the generation of high-functionality excipients for tablet formulation. In the present study, comparative analysis of the powder and tableting properties of three co-processed starches prepared by…
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