Pharma Excipients
Starch
Role of additives in starch-based edible films and coating: A review with current knowledge
Edible films and coating provide a potentially effective method for preserving fresh food products by reducing moisture loss, regulating respiration rate, improving surface smoothness, and or preventing microbial growth during their storage. Concurrently, starch has proven for its inexpensive,…
Read More...
Read More...
Taste Detection of Maltooligosaccharides with Varying Degrees of Polymerization
Previous studies have shown that humans can taste maltooligosaccharides but not maltopolysaccharides (MPS; DP of >20) and that their taste detection is independent of the canonical sweet taste receptor. The objectives of this study were to determine the DP ranges of target stimuli that are…
Read More...
Read More...
Entrapment of celecoxib into mesoporous silica particles for tablets with improved dissolution…
The objective of this study was to develop mesoporous silica particles (MSPs) tablet that can entrap large amounts of celecoxib into the mesopores as an amorphous state, exhibiting an enhanced dissolution. Optimal conditions that enable high drug loading into MSPs were investigated. The…
Read More...
Read More...
Tableting of fluidized bed granules containing living microorganisms
Tablets are the favored dosage form for numerous active pharmaceutical ingredients, among others because they are easy to take, ensure safe dosing and allow cost-effective production on a large scale. This dosage form is also frequently chosen for the administration of viable probiotic …
Read More...
Read More...
High-Speed Tableting of High Drug-Loaded Tablets Prepared from Fluid-Bed Granulated Isoniazid
The aim of this feasibility study was to investigate the possibility of producing industrial-scale relevant, robust, high drug-loaded (90.9%, w/w) 100 mg dose immediate-release tablets of isoniazid and simultaneously meet the biowaiver requirements. With an understanding of the real-life…
Read More...
Read More...
The distribution of Drucker-Prager Cap model parameters for pharmaceutical materials
A model of the compaction process that has come into increasing use with the pharmaceutical industry is the Drucker-Prager Cap model (DPC). It has long been used in conjunction with the finite element methods to simulate the density and stress distributions in compacts. More recently the calibrated…
Read More...
Read More...
Impact of Tablet Size and Shape on the Swallowability in Older Adults
Older adults represent the major target population for oral medications, due to the high prevalence of multimorbidity. To allow for successful pharmacological treatments, patients need to adhere to their medication and, thus, patient-centric drug products with a high level of acceptability by the…
Read More...
Read More...
Effect of Precompression on Capping Tendency
Compaction simulators are a key technology allowing scientists to develop formulations and troubleshoot tablet defects. It means that formulation scientists or tech transfer engineers can assess the influence of process parameters on tablet properties to preempt risk during scale-up or to solve…
Read More...
Read More...
Preparation and Evaluation of a Dosage Form for Individualized Administration of Lyophilized…
Probiotics have been used in human and veterinary medicine to increase resistance to pathogens and provide protection against external impacts for many years. Pathogens are often transmitted to humans through animal product consumption. Therefore, it is assumed that probiotics protecting animals may…
Read More...
Read More...
Anionic and Ampholytic High-Amylose Starch Derivatives as Excipients for Pharmaceutical and…
Many chemical modifications of starch are realized in organic (mostly methanol) phase, allowing high degrees of substitution (DS). Some of these materials are used as disintegrants. To expand the usage of starch derivative biopolymers as drug delivery system, various starch derivatives obtained in…
Read More...
Read More...