A study of anionic, cationic, and nonionic surfactants modified starch nanoparticles for hydrophobic drug loading and release

Starch nanoparticles were prepared from native potato starch using acid hydrolysis and precipitation methods.

The acid hydrolysis method yielded high relative crystallinity of starch nanoparticles (SNP-H), while ethanol precipitation method resulted in nanoparticles (SNP-P) with low crystallinity, which shows a broad peak in diffractogram. SNP-P has higher drug loading capacity than SNP-H.

Microfluidic preparation and optimization of Kollicoat ® IR-b-PCL polymersome for co-delivery of Nisin-Curcumin in breast cancer application

Dual encapsulation and sequential release of cisplatin and vitamin E from soy polysaccharides and β-cyclodextrin bioadhesive hydrogel nanoparticles

Tablet ejection: A systematic comparison between force, static friction, and kinetic friction

The modification of nanoparticles using CTAB resulted in the highest drug loading compared to SDS and Tween 20. A sustained release mechanism at pH 5.8 and 7.4 was observed for SNP-H. Anionic surfactant modified SNP shows the burst release in the initial time of drug release.

The cumulative release is lower at pH 5.8 than pH 7.4. The simple sigmoidal function and Higuchi model were used to represent the kinetic release profile of Paclitaxel from starch nanoparticles. Cytotoxicity assay of the original nanoparticles showed good biocompatibility of nanoparticles with 7F2 cells. More on starch nano particles

excipients