Trehalose

The present study compared vacuum drum drying (VDD) and conventional spray drying (SD) for solidifying crystalline ABT-199 nanosuspensions into redispersible oral drug products. The aim was to optimize formulation compositions and process conditions to maintain nanoparticle size after tablet…
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Nagase Viita Co., Ltd. (Headquarters: Shimoishii, Kita-ku, Okayama; Representative Director: Naoki Yasuba), a member of the NAGASE Group, has launched a new product brand, SOLBIOTETM, featuring their saccharide-based pharmaceutical excipients of high-purity and low-endotoxin TREHALOSE SG and MALTOSE…
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Founded as a starch syrup manufacturer in 1883, Nagase Viita (Formerly Hayashibara Co., Ltd.)  has grown into a company with strong research and development expertise, engaging in original and creative research. We present the latest brochure "For Culture Media Use - Trehalose SG by Nagase Viita":…
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BioHale® is  DFE Pharma´s, high-purity, low-endotoxin product portfolio for the stabilization of biologics. Because stability matters. BioHale® Key promises: Uncompromised quality Security of supply Expert support Uncompromised quality BioHale® high purity and low endotoxin…
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Reversible protein precipitates (protein microbeads) have been developed using Shirasu porous glass (SPG) membrane emulsification. Microbeads have a mean size of a few micrometers (2–5 μm), and their formation is reversible upon rehydration. Their feasibility was examined as dry powders for…
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Most of biopharmaceuticals, in their liquid form, are prone to instabilities during storage. In order to improve their stability, lyophilization is the most commonly used drying technique in the pharmaceutical industry. In addition, certain applications of biopharmaceutical products can be…
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Abstract Background Traumatic brain injury (TBI) is the most common cause of cognitive and behavioral deficits, disability, and mortality worldwide. Trehalose is a natural non-reducing disaccharide of glucose which its anti-inflammatory and anti-oxidative stress effects have been proven in past…
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A dry powder inhaled liposomal azithromycin formulation was developed for the treatment of chronic respiratory diseases such as cystic fibrosis and bronchiectasis. Key properties including liposome size, charge and encapsulation efficiency powder size, shape, glass transition temperature (Tg), water…
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Successful oral delivery of liposomes requires formulations designed to withstand harsh gastrointestinal conditions, e.g., by converting to solid-state followed by loading into gastro-resistant delivery devices. The hypothesis was that the use of dextran-trehalose mixtures for spray drying would…
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Spray drying microencapsulation has emerged as a promising technique for producing highly active probiotic powders. The efficient delivery of live probiotics to their target site, particularly the intestinal tract, is crucial for their therapeutic effectiveness. This study aimed to investigate the…
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