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Trehalose
Spray dried VSV-vectored vaccine is thermally stable and immunologically active in vivo
Effective vaccine delivery and coverage to rural and resource-poor countries is hindered by the dependence on cold chain storage. As such, developments of cold chain-free technologies are highly sought. Although spray dried adenoviral vectors have shown long term stability at ambient temperatures…
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VaxiPatch™, a novel vaccination system comprised of subunit antigens, adjuvants and microneedle skin…
This work introduces VaxiPatch, a novel vaccination system comprised of subunit glycoprotein vaccine antigens, adjuvants and dermal delivery. For this study, rHA of influenza virus B/Colorado/06/2017 was incorporated into synthetic virosomes, and adjuvant liposomes were formed with QS-21 from…
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Stabilizing Enzymes within Polymersomes by Co-Encapsulation of Trehalose
Enzymes are essential biocatalysts and very attractive as therapeutics. However, their functionality is strictly related to their stability, which is significantly affected by the environmental changes occurring during their usage or long-term storage. Therefore, maintaining the activity of enzymes…
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Polymeric Materials to Improve the Stability and Delivery of Insulin and Glucagon
Proteins and peptides have become an important class of therapeutics due to their high specificity and general biocompatibility. However, using proteins and peptides as drugs has several intrinsic challenges. These macromolecules are generally cleared rapidly due to renal filtration and enzymatic…
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Formation of nanoparticles for the oral delivery of small molecules by Flash Nanoprecipitation
Nanoparticles have shown considerable potential in many biological applications including drug delivery, bio-imaging, and medical diagnostics. Specifically, the development of nanoparticle-based drug formulations holds opportunities to improve the dissolution rate and oral availability of poorly…
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Lyophilisation Improves Bioactivity and Stability of Insulin-Loaded Polymeric-Oligonucleotide…
The oral bioavailability of therapeutic proteins is limited by the gastrointestinal barriers. Encapsulation of labile proteins into nanoparticles is a promising strategy. In order to improve the stability of nanoparticles, lyophilisation has been used to remove water molecules from the suspension.…
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Pfanstiehl Inc, USA- Helping accelerate COVID19 research to develop Vaccine, Diagnosis and Cure
Pfanstiehl (IL, USA) is a global leader in developing High Pure/Low Endotoxin Viral Vector, Protein and Vaccine stabilizers ( eg. HPLE-Trehalose, Sucrose, Histidine, Arginine ,Mannitol, Sodium Succinate etc.) that are used in producing many human vaccines and diagnostics worldwide.
As the global…
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A Theoretical Study on Trehalose + Water Mixtures for Dry Preservation Purposes
The properties of trehalose + water mixtures are studied as a function of mixture composition and temperature using molecular dynamics simulations. As trehalose disaccharide has been proposed for dry preservation purposes, the objective of this work is to analyse the nanoscopic properties of the…
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Formation of protein sub-visible particles during powder grinding of a monoclonal antibody
We have observed an interesting phenomenon in which grinding of freeze-dried monoclonal antibody X (mAb-X) formulation powder resulted to significant protein sub-visible particles (SbVPs) in the reconstituted liquid, which could only be observed by sensitive particle analytical methods such as MFI…
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Use of a temperature ramp approach (TRA) to design an optimum and robust freeze-drying process for…
Freeze-drying, until now, has been a process that was designed using a trial and error experimental approach. This approach is often material and time consuming, and the resulting freeze-drying processes are neither optimum nor robust. Accordingly, the objective of this study was to develop a…
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