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Trehalose
Excipients for the lyoprotection of MAPKAP kinase 2 inhibitory peptide nano-polyplexes
02. May 2018
Herein, excipients are investigated to ameliorate the deleterious effects of lyophilization on peptide-polymer nano-polyplex (NP) morphology, cellular uptake, and bioactivity. The NPs are a previously-described platform technology for intracellular peptide delivery and…
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The Preservation of Lyophilized Human Growth Hormone Activity: how Do Buffers and Sugars Interact?
02. May 2018
One of the most common classes of excipients used in protein formulations are buffers. The aim of this work is to investigate the effect of buffers on protein stabilization given by sugars during freeze drying.
Methods
Molecular Dynamics simulations of human…
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Comparison of melibiose and trehalose as stabilising excipients for spray-dried β-galactosidase…
26. March 2018
Spray-dried protein formulations commonly require stabilising excipients to prevent protein degradation during processing and storage, and trehalose has been commonly used. The purpose of this workwas to evaluate melibiose in spray-dried protein formulations in…
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Dry-powder formulations of non-covalent protein complexes
10. February 2018
Abstract
Pulmonary delivery of protein therapeutics has considerable clinical potential for treating both local and systemic diseases. However, poor protein conformational stability, immunogenicity and protein degradation by proteolytic enzymes in the lung are…
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Stabilization of Glucagon by Trehalose Glycopolymer Nanogels
23. January 2018
Abstract
Glucagon is a peptide hormone used for the treatment of hypoglycemia; however, its clinical potential is limited by its insolubility and instability in solution. Herein, the encapsulation, stabilization, and release of glucagon by trehalose glycopolymer…
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Synthetic glycopolymers as modulators of protein aggregation – Novel excipients to stabilize…
22. January 2018
Novel drug excipients are required to achieve stable formulations of protein drug candidates. Synthetic glycopolymers have been shown in some cases to improve protein formulation stability, although their structure-function relationship remains unknown. Here we…
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Novel liposome-based and in situ gelling artificial tear formulation for dry eye disease treatment
14. December 2017
Purpose
Artificial tears are widely used in the treatment of dry eye disease, although current formulations do not closely resemble natural tears. The purpose of this study was the design and characterization of a novel in situ gelling artificial tear formulation,…
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Enhancing the viability of Lactobacillus rhamnosus GG after spray drying and during storage
08. October 2017
Increasing knowledge about the human microbiome has led to a growing awareness of the potential of applying probiotics to improve our health. The pharmaceutical industry shows an emerging interest in pharmaceutical formulations containing these beneficial microbes,…
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A comprehensive screening platform for aerosolizable protein formulations for intranasal and…
20. September 2017
Aerosolized administration of biopharmaceuticals to the airways is a promising route for nasal and pulmonary drug delivery, but − in contrast to small molecules − little is known about the effects of aerosolization on safety and efficacy of…
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Microencapsulated Solid Lipid Nanoparticles as a Hybrid Platform for Pulmonary Antibiotic Delivery
21. August 2017
Solid lipid nanoparticles (SLN) containing rifabutin (RFB), with pulmonary administration purposes, were developed through a technique that avoids the use of organic solvents or sonication. To facilitate their pulmonary delivery, the RFB-loaded SLN were included in…
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