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Trehalose
Development of a solid dosage platform for the oral delivery of bilayer vesicles
19. June 2017
Abstract
Within this work, we develop vesicles incorporating sub-unit antigens as solid dosage forms suitable for the oral delivery of vaccines. Using a combination of trehalose, dextran and mannitol, freeze-dried oral disintegrating tablets were formed which upon…
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Investigation of nanocarriers and excipients for preparation of nanoembedded microparticles
10. May 2017
Abstract
Colloidal drug delivery systems often face physical and chemical instability as well as challenges with directed delivery. In order to overcome these challenges the colloidal formulations can be processed into microparticulate form (nanoembedded…
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Bilateral Effects of Excipients on Protein Stability: Preferential Interaction Type of Excipient and…
16. April 2017
Purpose
Understanding the mechanism of protein-excipient interaction and illuminating the influencing factors on protein stability are key steps in the rational design of protein formulations. The objective of this study was to assess effects of preferential…
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Applications of glycopolymer libraries as protein aggregation modulators and drug delivery systems
20. January 2017
Abstract
The biopharmaceutical market has been on the rise for the past two decades and is expected to continue to excel, currently presenting a growing rate of more than double than conventional pharma. Traditionally this growth has been hindered by multiple…
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Trehalose monooleate: a potential anti- aggregation agent for stabilization of proteins
18. October 2016
Protein aggregation is a major problem of therapeutic proteins because aggregation decreases their therapeutic activity, shelf life and induces immunogenicity. Stabilization against aggregation is commonly attained by addition of different excipients like sugars,…
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Spray-dried amorphous isomalt and melibiose, two potential protein-stabilizing excipients
20. June 2016
Abstract
The possibility of producing amorphous isomalt and melibiose by spray drying was studied. The impact of process parameters on yield and solid-state stability was compared to sucrose and trehalose. All powders remained amorphous during 2–3 weeks. Processing was…
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Evaluation of excipients for enhanced thermal stabilization of a human type 5 adenoviral vector…
01. May 2016
We have produced a thermally stable recombinant human type 5 adenoviral vector (AdHu5) through spray drying with three excipient formulations (l-leucine, lactose/trehalose and mannitol/dextran). Spray drying leads to immobilization of the viral vector which is believed to prevent…
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Controlled Release of Multiple Therapeutics from Silicone Hydrogel Contact Lenses
13. March 2016
Purpose: The majority of contact lens wearers experience a significant level of ocular discomfort associated with lens wear, often within hours of wear, related to dry lenses, inflammation, protein adhesion to the lens surface, etc. Application of controlled drug…
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Trehalose: Current Use and Future Applications – Article 2010
25. November 2015
Trehalose, a disaccharide of glucose, has been reported to accumulate in many organisms that can withstand extended periods of inanimation. Since this discovery, the properties of trehalose have been examined extensively to understand its role and abundance in nature.…
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Trehalose: A Powerful Excipient in the Formulation Toolbox – Product Information
By: Ben Nelson, PhD, and Chris Wilcox
Trehalose is a non-reducing disaccharide consisting of two glucose molecules linked by an α,α–1,1 glycosidic bond. In the pharmaceutical industry, products that benefit from the stabilizing effects of trehalose include, but are not limited…
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