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Trehalose
Nagase/Hayashibara will be attending the AAPS 2023 PharmSci 360 in Orlando
Press release
Nagase/Hayashibara will be attending the AAPS 2023 PharmSci 360 in Orlando, FL, USA.
AAPS 2023 PharmSci 360 in Orlando, FL, Orange County Convention Center
Nagase/Hayashibara Booth #3046
Poster Session M0930-04-23, Oct 23, 9:30-10:30
Title: Beneficial Effects of Trehalose…
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Structural modifications for the conversion of proteins and peptides into stable dried powder…
The drying of biomolecules into powdered formulations has become the main form of long-term product stabilisation, allowing for the delivery of safe and efficient medicines. Stability of proteins and peptides during the drying process is paramount for product quality. Drying macromolecules with an…
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Lyophilized Lipid Liquid Crystalline Nanoparticles as an Antimicrobial Delivery System
Lipid liquid crystalline nanoparticles (LCNPs) are unique nanocarriers that efficiently deliver antimicrobials through biological barriers. Yet, their wide application as an antimicrobial delivery system is hindered by their poor stability in aqueous dispersions. The production of dried LCNP powder…
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Live Biotherapeutics: importance of formulation and lyophilization parametersand an example of a…
In recent years, probiotics have expanded from their traditional classification as “health promoting food” to the development of live biotherapeutic products (LBP). Traditional probiotics are marketed as food/dietary supplements while LBPs are drug products intended for treatment or prevention of…
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Nanoparticulate impurities in the pharmaceutical excipient trehalose induce an early immune response
Abstract
Background
Pharmaceutical excipients are an important part of biological products. However, few attempts have been made to distinguish between the risk of inflammation associated with the biological products themselves and that associated with excipients. The analysis of early immune…
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A Comprehensive Scientific Survey of Excipients Used in Currently Marketed, Therapeutic Biological…
Purpose
The steady development of biotechnology-derived therapeutic biologics over the last few decades has generated drugs that are now standard medical treatments for a range of indications. While the development of protein products has surged in recent years, the formulation and delivery of…
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Formulation of antiretroviral nanocrystals and development into a microneedle delivery system for…
HIV/AIDS remains a major global public health issue. While antiretroviral therapy is effective at reducing the viral load in the blood, up to 50% of those with HIV suffer from some degree of HIV-associated neurocognitive disorder, due to the presence of the blood–brain barrier restricting drugs from…
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Deciphering the Structure-Property Relationship and Antioxidant Mechanisms of Trehalose – An…
Reactive Oxygen Species (ROS) have attracted significant attention among researchers as they play a role in cell death when produced excessively. To address this issue, scientists are actively seeking suitable antioxidants that can counteract the effects of ROS. Trehalose, a disaccharide molecule…
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A systematic review of commercial high concentration antibody drug products approved in the US:…
Three critical aspects that define high concentration antibody products (HCAPs) are as follows: 1) formulation composition, 2) dosage form, and 3) primary packaging configuration. HCAPs have become successful in the therapeutic sector due to their unique advantage of allowing subcutaneous…
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Ranking mAb–excipient interactions in biologics formulations by NMR spectroscopy and computational…
ABSTRACT
Excipients are added to biopharmaceutical formulations to enhance protein stability and enable the development of robust formulations with acceptable physicochemical properties, but the mechanism by which they confer stability is not fully understood. Here, we aimed to elucidate the…
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