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Paediatric
3D printed dispersible efavirenz tablets: A strategy for nasogastric administration in children
Enteral feeding tubes (EFTs) can be placed in children diagnosed with HIV which need nutritional support due to malnutrition. EFTs are the main route for medication administration in these patients, bringing up concerns about off label use of medicines, dose inaccuracy and tube clogging. Here we…
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Novel Patient-Friendly Orodispersible Formulation of Ivermectin is Associated With Enhanced…
Abstract
Ivermectin has been used since the 1980s as an anthelmintic and antiectoparasite agent worldwide. Currently, the only available oral formulation is tablets designed for adult patients. A patient-friendly orodispersible tablet formulation designed for pediatric use (CHILD-IVITAB) has been…
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Is it advantageous to use quality by design (QbD) to develop nanoparticle-based dosage forms for…
Abstract
Parenteral administration is one of the most commonly used drug delivery routes for nanoparticle-based dosage forms, such as lipid-based and polymeric nanoparticles. For the treatment of various diseases, parenteral administration include intravenous, subcutaneous, and intramuscular…
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Pediatric Drug Delivery Challenges: Enhancing Compliance Through Age-appropriate Formulations and…
Abstract
Pediatric pharmacotherapy presents distinctive challenges compared with adult pharmacotherapy and encompasses considerations such as drug administration methods, susceptibility to medication-related toxicity, and taste preferences that influence compliance and efficacy. Customizing…
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Paediatric clinical study of 3D printed personalised medicines for rare metabolic disorders
Rare diseases are infrequent, but together they affect up to 6–10 % of the world’s population, mainly children. Patients require precise doses and strict adherence to avoid metabolic or cardiac failure in some cases, which cannot be addressed in a reliable way using pharmaceutical compounding. 3D…
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Innovative pharmaceutical techniques for Paediatric dosage forms: a systematic review on 3D…
The production of paediatric pharmaceutical forms represents a unique challenge within the pharmaceutical industry. The primary goal of these formulations is to ensure therapeutic efficacy, safety, and tolerability in paediatric patients, who have specific physiological needs and characteristics. In…
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Pediatric Formulations Developed by Extrusion-Based 3D Printing: From Past Discoveries to Future…
Abstract
Three-dimensional printing (3DP) technology in pharmaceutical areas is leading to a significant change in controlled drug delivery and pharmaceutical product development. Pharmaceutical industries and academics are becoming increasingly interested in this innovative technology due to its…
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The challenge of downstream processing of spray dried amorphous solid dispersions into minitablets…
Poorly water-soluble drugs present a significant challenge in the development of oral solid dosage forms (OSDs). In formulation development the appropriate use of excipients to adjust solubility, and the choice of manufacturing method and pharmaceutical processes to obtain a dosage form to meet the…
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A Multi-Particulate Formulation of Pantoprazole Based on Enteric Coated Minitablets
JRS Pharma presented three posters at the 2024 PBP World Meeting in Vienna. This is the first poster:
Introduction
Multiparticulate systems provide solutions to some of the main challenges found with gastro-resistant formulations, namely dose dumping, unpredictable gastric retention time, and lack…
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Application of 3D printing technology for the development of dose adjustable geriatric and pediatric…
Abstract
Developing safe and effective formulations for the geriatric and pediatric population is a challenging task due to issues of swallowability and palatability. The lack of standardized procedures for pediatric formulations further complicates the process. Manipulating adult formulations…
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