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Paediatric
Inhaled Dry Powder Mannitol Treatment in Pediatric Patients with Cystic Fibrosis: Evaluation of…
Background: Cystic fibrosis (CF) is a genetic disorder, in which defective clearance of airway secretions leads to progressive lung function loss. Inhaled mannitol is used to increase sputum and mucociliary clearance. There are little data from real-world studies on the effectiveness of mannitol in…
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Vehicles for Drug Administration to Children: Results and Learnings from an In-Depth Screening of…
Purpose
Mixing with liquids or soft foods is a common procedure to improve acceptability of oral medicines in children but may affect drug stability and the in vivo performance of the administered drug product. The aim of the present study was to obtain an overview of the variability of critical…
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The determination of Sulfobutylether β-Cyclodextrin Sodium (SBECD) by LC-MS/MS and its Application…
SBECD (Captisol®) with an average degree of substitution of 6.5 sulfobutylether functional groups (SBE = 6.5), is a solubility enhancer for remdesivir (RDV) and a major component in Veklury, which was approved by FDA for the treatment of patients with COVID-19 over 12 years old and weighing over 40 …
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Dosage Forms Suitability in Pediatrics: Acceptability of Analgesics and Antipyretics in a German…
Although medicine acceptability is likely to have a significant impact on the patient’s adherence in pediatrics and therefore on therapy success, there is still little data even for common therapeutic areas. For analgesics/antipyretics, healthcare professionals face a wide variety of products and…
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Paediatric specific dosage forms: Patient and formulation considerations
The total number of paediatric formulations available only account for a small proportion of the full therapeutic plethora required to effectively treat paediatrics and, therefore, the availability of high quality medicines designed specifically for children remains an ongoing challenge. At present,…
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Mini-Tablets: A Valid Strategy to Combine Efficacy and Safety in Pediatrics
In the treatment of pediatric diseases, mass-produced dosage forms are often not suitable for children. Commercially available medicines are commonly manipulated and mixed with food by caregivers at home, or extemporaneous medications are routinely compounded in the hospital pharmacies to treat…
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Development and Evaluation of an In Silico Dermal Absorption Model Relevant for Children
The higher skin surface area to body weight ratio in children and the prematurity of skin in neonates may lead to higher chemical exposure as compared to adults. The objectives of this study were: (i) to provide a comprehensive review of the age-dependent anatomical and physiological changes in…
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ExciPerience – Early Bird sale ends on January 31st
ExciPerience is the virtual event around every aspect of pharmaceutical excipients. ExciPerience covers all areas from basic or advanced research and formulation to manufacturing and regulatory. There will be more and new possibilities for personal interaction and different presentation formats than…
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Performance Evaluation of Montelukast Pediatric Formulations: Part II — a PBPK Modelling Approach
This study aimed to build a physiologically based pharmacokinetic (PBPK) model coupled with age-appropriate in vitro dissolution data to describe drug performance in adults and pediatric patients. Montelukast sodium was chosen as a model drug. Two case studies were investigated: case study 1 focused…
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Manipulations and age-appropriateness of oral medications in pediatric oncology patients in Sweden:…
Due to the lack of age-appropriate formulations for children, healthcare professionals and caregivers frequently manipulate dosage forms to facilitate oral administration and obtain the required dose. In this study, we investigated drug manipulation and age-appropriateness of oral medications for…
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