Browsing Category
Paediatric
Review of paediatric gastrointestinal physiology relevant to the absorption of orally administered…
Despite much progress in regulations to improve paediatric drug development, there remains a significant need to develop better medications for children. For the design of oral dosage forms, a detailed understanding of the specific gastrointestinal (GI) conditions in children of different age…
Read More...
Read More...
European Paediatric Formulary: two draft texts released for public consultation
The European Directorate for the Quality of Medicines & HealthCare (EDQM) has just released Issue 4 of Pharmeuropa PaedForm, which contains two texts for public consultation, Simple syrup (preservative-free) and Phosphate 60 mg/mL Oral solution, prior to their inclusion in the European…
Read More...
Read More...
Quality of FDM 3D Printed Medicines for Pediatrics: Considerations for Formulation Development,…
3d printing is capable of providing dose individualization for pediatric medicines and translating the precision medicine approach into practical application. In pediatrics, dose individualization and preparation of small dosage forms is a requirement for successful therapy, which is frequently not…
Read More...
Read More...
Acceptability of different oral dosage forms in paediatric patients in hospital setting
Objective The understanding of acceptability of existing dosage forms is limited in most of the world and hinders the development of acceptable, age‐appropriate medicines. The attributes of paediatric medicine acceptability may differ from country to country based on culture, healthcare…
Read More...
Read More...
Formulation development and evaluation of taste masked anthelmintics chewable tablets by using…
The aim of the current study is to develop and evaluate patient friendly taste masked anthelmintics chewable tablets for pediatrics and geriatrics use. However, the chewable tablets have to disintegrate in the mouth before swallowing, which makes the chewable tablet dosage forms inappropriate for…
Read More...
Read More...
Combined Use of Cyclodextrins and Amino Acids for the Development of Cefixime Oral Solutions for…
Cefixime (CEF) is a cephalosporin included in the WHO Model List of Essential Medicines for Children. Liquid formulations are considered the best choice for pediatric use, due to their great ease of administration and dose-adaptability. Owing to its very low aqueous solubility and poor stability,…
Read More...
Read More...
Development and in-vitro in-vivo characterization of in-situ gelling sustained-release nevirapine…
Nevirapine is a BCS class-II drug used in the treatment and prevention of HIV/AIDS, specifically HIV-1. This study was aimed to develop and evaluate a novel pH-responsive in-situ gelling sustained-release nevirapine pediatric suspension (SRNPS) for treatment and prevention of mother-to-child…
Read More...
Read More...
Acceptability of small-sized oblong tablets in comparison to syrup and mini-tablets in infants and…
Objective
There is limited evidence for the acceptability of various drug formulations holding the potential to improve medicines administration to children. Suitable formulations need to meet the requirements of pediatric patients. Previous studies have demonstrated the acceptance of…
Read More...
Read More...
Utilising Co-Axial Electrospinning as a Taste-Masking Technology for Paediatric Drug Delivery
The present study describes the use of two taste-masking polymers to fabricate a formulation of chlorpheniramine maleate for paediatric administration. Co-axial electrospinning was utilized to create layered nanofibres; the two polymers, Eudragit® E PO and Kollicoat® Smartseal, were alternated…
Read More...
Read More...
Investigating the Critical Variables of Azithromycin Oral Absorption Using In Vitro Tests and PBPK…
Azithromycin is an antibiotic listed in the essential list of medicines for adults and pediatrics. Conflicting evidence has been found regarding azithromycin classification according to the Biopharmaceutics classification system (BCS). The purpose of this study was to identify the critical variables…
Read More...
Read More...