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Paediatric
In-vitro and in-vivo evaluation of taste-masked ibuprofen formulated in oral dry emulsions
Objective
The aim of this study was to develop a paediatric oral preparation for ibuprofen.
Significance
Ibuprofen is widely used for defervescence in children, but medication compliance is poor due to its bitter taste. Dry emulsions possess good stability and can be transported and stored…
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Orodispersible films: Conception to quality by design
Orodispersible films (ODFs) are pharmaceutical dosage forms that do not need water to be ingested. Perfect for paediatrics and geriatrics
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Accuracy of Dose Administered to Children Using Off-Labelled or Unlicensed Oral Dosage Forms
The pediatric population suffers from a lack of age-appropriate medicines leading to unsafe situations when off-labelled or unlicensed drugs are used. Assessing the best option to administrate medicines when manipulations are required is essential in order to improve child care. This study aimed to…
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Evaluation of two novel co-processed excipients for direct compression of orodispersible tablets and…
Pediatric, geriatric, and other patients who suffer from swallowing difficulties represent a special patient group, where an increased need in appropriate formulation development is required. To overcome these mostly swallowability linked issues, orodispersible tablets (ODTs) and orodispersible…
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Implementing risk-based quality by design for development and optimization of flavored oral…
Paediatric patients differ from adult in various aspects of pharmacotherapy, including the abilities of drug admistration, medicine related toxicity and taste partialities. It is very much important that paediatrics drugs should best fit the child's size, age, various physiologic conditions of the…
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Utilization of Ethylcellulose Microparticles with Rupatadine Fumarate in Designing Orodispersible…
Minitablets in orodispersible form constitute a flexible drug delivery tool for paediatric and geriatric population as they eliminate the risk of chocking and do not require drinking water in the application. Due to their direct contact with taste buds, taste sensation is an important factor.…
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Personalised Tasted Masked Chewable 3D Printed Fruit-Chews for Paediatric Patients
The development of personalised paediatric dosage forms using 3D printing technologies has gained significant interest over the last few years. In the current study extruded filaments of the highly bitter Diphenhydramine Hydrochloride (DPH) were fabricated by using suitable hydrophilic carries such…
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3D printing of drugs: expanding the options for child-tailored pharmacotherapy
Lack of age-appropriate commercially available drugs hinders adequate pharmacotherapy in children. The European Union Paediatric Regulation (EC No1901/2006) and the establishment of the EU Paediatric Committee PDCO (2007) were aimed to stimulate research into the use of medicines in children and to…
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Direct Powder Extrusion 3D Printing of Praziquantel to Overcome Neglected Disease Formulation…
For the last 40 years, praziquantel has been the standard treatment for schistosomiasis, a neglected parasitic disease affecting more than 250 million people worldwide. However, there is no suitable paediatric formulation on the market, leading to off-label use and the splitting of commercial…
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Potential pharmacokinetic interaction between orally administered drug and osmotically active…
Poorly absorbable sugar alcohols (e.g., mannitol, sorbitol, and maltitol) are the excipients frequently contained in pediatric dosage forms. Due to their osmotically active properties, certain amount of sugar alcohols reportedly reduces oral bioavailability of concomitant drugs. This fact implies…
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